Robert R McWilliams1, Patrick Maisonneuve, William R Bamlet, Gloria M Petersen, Donghui Li, Harvey A Risch, Herbert Yu, Elizabeth T H Fontham, Brian Luckett, Cristina Bosetti, Eva Negri, Carlo La Vecchia, Renato Talamini, H Bas Bueno de Mesquita, Paige Bracci, Steven Gallinger, Rachel E Neale, Albert B Lowenfels. 1. From the *Department of Oncology, Mayo Clinic, Rochester, MN; †Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy; ‡Division of Biostatistics, Mayo Clinic; §Department of Health Sciences Research, Mayo Clinic, Rochester, MN; ∥Department of Gastrointestinal Medical Oncology, UT MD Anderson Cancer Center, Houston, TX; ¶Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT; #Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI; **Louisiana State University School of Public Health, New Orleans, LA; ††Tulane School of Public Health, New Orleans, LA; ‡‡Department of Epidemiology, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri," and §§Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy; ∥∥S.O.C. Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, IRCCS, Aviano (PN), Italy; ¶¶National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands; School of Public Health, Imperial College London, London, United Kingdom; ##Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA; ***Division of General Surgery, University of Toronto, Toronto, Ontario, Canada; †††Cancer and Population Studies Group, QIMR Berghofer Medical Research Institute, Brisbane, Australia; and ‡‡‡Department of Surgery, Department of Family Medicine, New York Medical College, Valhalla, NY.
Abstract
OBJECTIVES: While pancreatic cancer (PC) most often affects older adults, to date, there has been no comprehensive assessment of risk factors among PC patients younger than 60 years. METHODS: We defined early-onset PC (EOPC) and very-early-onset PC (VEOPC) as diagnosis of PC in patients younger than 60 and 45 years, respectively. We pooled data from 8 case-control studies, including 1954 patients with EOPC and 3278 age- and sex-matched control subjects. Logistic regression analysis was performed to identify associations with EOPC and VEOPC. RESULTS: Family history of PC, diabetes mellitus, smoking, obesity, and pancreatitis were associated with EOPC. Alcohol use equal to or greater than 26 g daily also was associated with increased risk of EOPC (odds ratio, 1.49; 95% confidence interval, 1.21-1.84), and there appeared to be a dose- and age-dependent effect of alcohol on risk. The point estimate for risk of VEOPC was an odds ratio of 2.18 (95% confidence interval, 1.17-4.09). CONCLUSIONS: The established risk factors for PC, including smoking, diabetes, family history of PC, and obesity, also apply to EOPC. Alcohol intake appeared to have an age-dependent effect; the strongest association was with VEOPC.
OBJECTIVES: While pancreatic cancer (PC) most often affects older adults, to date, there has been no comprehensive assessment of risk factors among PC patients younger than 60 years. METHODS: We defined early-onset PC (EOPC) and very-early-onset PC (VEOPC) as diagnosis of PC in patients younger than 60 and 45 years, respectively. We pooled data from 8 case-control studies, including 1954 patients with EOPC and 3278 age- and sex-matched control subjects. Logistic regression analysis was performed to identify associations with EOPC and VEOPC. RESULTS: Family history of PC, diabetes mellitus, smoking, obesity, and pancreatitis were associated with EOPC. Alcohol use equal to or greater than 26 g daily also was associated with increased risk of EOPC (odds ratio, 1.49; 95% confidence interval, 1.21-1.84), and there appeared to be a dose- and age-dependent effect of alcohol on risk. The point estimate for risk of VEOPC was an odds ratio of 2.18 (95% confidence interval, 1.17-4.09). CONCLUSIONS: The established risk factors for PC, including smoking, diabetes, family history of PC, and obesity, also apply to EOPC. Alcohol intake appeared to have an age-dependent effect; the strongest association was with VEOPC.
Authors: P Boyle; P Maisonneuve; B Bueno de Mesquita; P Ghadirian; G R Howe; W Zatonski; P Baghurst; C J Moerman; A Simard; A B Miller; K Przewoniak; A J McMichael; C C Hsieh; A M Walker Journal: Int J Cancer Date: 1996-07-03 Impact factor: 7.396
Authors: L Wideroff; G Gridley; L Mellemkjaer; W H Chow; M Linet; S Keehn; K Borch-Johnsen; J H Olsen Journal: J Natl Cancer Inst Date: 1997-09-17 Impact factor: 13.506
Authors: Ted A James; David G Sheldon; Ashwani Rajput; Boris W Kuvshinoff; Milind M Javle; Hector R Nava; Judy L Smith; John F Gibbs Journal: Cancer Date: 2004-12-15 Impact factor: 6.860
Authors: A B Lowenfels; P Maisonneuve; G Cavallini; R W Ammann; P G Lankisch; J R Andersen; E P Dimagno; A Andrén-Sandberg; L Domellöf Journal: N Engl J Med Date: 1993-05-20 Impact factor: 91.245
Authors: Jessica L Petrick; Nelsy Castro-Webb; Hanna Gerlovin; Traci N Bethea; Shanshan Li; Edward A Ruiz-Narváez; Lynn Rosenberg; Julie R Palmer Journal: Cancer Epidemiol Biomarkers Prev Date: 2020-07-01 Impact factor: 4.254
Authors: Jason M Link; Shannon M Liudahl; Courtney B Betts; Shamilene Sivagnanam; Kenna R Leis; Mary McDonnell; Carl R Pelz; Brett Johnson; Kelly J Hamman; Dove Keith; Jone E Sampson; Terry K Morgan; Charles D Lopez; Lisa M Coussens; Rosalie C Sears Journal: JCO Precis Oncol Date: 2021-02-05
Authors: Lily V Saadat; Joanne F Chou; Mithat Gonen; Kevin C Soares; T Peter Kingham; Anna M Varghese; William R Jarnagin; Michael I D'Angelica; Jeffrey A Drebin; Eileen M O'Reilly; Alice C Wei Journal: Cancer Date: 2021-07-06 Impact factor: 6.921