Literature DB >> 26644404

Role of Deubiquitinating Enzymes in DNA Repair.

Younghoon Kee1, Tony T Huang2.   

Abstract

Both proteolytic and nonproteolytic functions of ubiquitination are essential regulatory mechanisms for promoting DNA repair and the DNA damage response in mammalian cells. Deubiquitinating enzymes (DUBs) have emerged as key players in the maintenance of genome stability. In this minireview, we discuss the recent findings on human DUBs that participate in genome maintenance, with a focus on the role of DUBs in the modulation of DNA repair and DNA damage signaling.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26644404      PMCID： PMC4751696          DOI： 10.1128/MCB.00847-15

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  243 in total

1.  Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair.

Authors:  Yuanshu Dong; Mohamed-Ali Hakimi; Xiaowei Chen; Easwari Kumaraswamy; Neil S Cooch; Andrew K Godwin; Ramin Shiekhattar
Journal:  Mol Cell       Date:  2003-11       Impact factor: 17.970

2.  A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.

Authors:  Yingli Sun; Xiaofeng Jiang; Shujuan Chen; Norvin Fernandes; Brendan D Price
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-02       Impact factor: 11.205

Review 3.  A genomic and functional inventory of deubiquitinating enzymes.

Authors:  Sebastian M B Nijman; Mark P A Luna-Vargas; Arno Velds; Thijn R Brummelkamp; Annette M G Dirac; Titia K Sixma; René Bernards
Journal:  Cell       Date:  2005-12-02       Impact factor: 41.582

4.  The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme.

Authors:  Younghoon Kee; Nancy Lyon; Jon M Huibregtse
Journal:  EMBO J       Date:  2005-06-02       Impact factor: 11.598

Review 5.  Redox redux: revisiting PTPs and the control of cell signaling.

Authors:  Nicholas K Tonks
Journal:  Cell       Date:  2005-06-03       Impact factor: 41.582

6.  A single-stranded DNA-binding protein is needed for efficient presynaptic complex formation by the Saccharomyces cerevisiae Rad51 protein.

Authors:  T Sugiyama; E M Zaitseva; S C Kowalczykowski
Journal:  J Biol Chem       Date:  1997-03-21       Impact factor: 5.157

7.  Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase.

Authors:  P Sung
Journal:  Genes Dev       Date:  1997-05-01       Impact factor: 11.361

8.  BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage.

Authors:  Alan R Schoenfeld; Sarah Apgar; Georgia Dolios; Rong Wang; Stuart A Aaronson
Journal:  Mol Cell Biol       Date:  2004-09       Impact factor: 4.272

9.  The 70 kDa subunit of replication protein A is required for the G1/S and intra-S DNA damage checkpoints in budding yeast.

Authors:  M P Longhese; H Neecke; V Paciotti; G Lucchini; P Plevani
Journal:  Nucleic Acids Res       Date:  1996-09-15       Impact factor: 16.971

Review 10.  Endogenous DNA damage in humans: a review of quantitative data.

Authors:  Rinne De Bont; Nik van Larebeke
Journal:  Mutagenesis       Date:  2004-05       Impact factor: 3.000
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  29 in total

Review 1.  Role of deubiquitinases in DNA damage response.

Authors:  John Le; Eric Perez; Leah Nemzow; Feng Gong
Journal:  DNA Repair (Amst)       Date:  2019-02-21

2.  The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair.

Authors:  Scott Cukras; Euiho Lee; Emily Palumbo; Pamela Benavidez; George-Lucian Moldovan; Younghoon Kee
Journal:  Cell Cycle       Date:  2016-07-27       Impact factor: 4.534

Review 3.  TGF-β signaling pathway mediated by deubiquitinating enzymes.

Authors:  Soo-Yeon Kim; Kwang-Hyun Baek
Journal:  Cell Mol Life Sci       Date:  2018-10-22       Impact factor: 9.261

4.  Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.

Authors:  Ilaria Lamberto; Xiaoxi Liu; Hyuk-Soo Seo; Nathan J Schauer; Roxana E Iacob; Wanyi Hu; Deepika Das; Tatiana Mikhailova; Ellen L Weisberg; John R Engen; Kenneth C Anderson; Dharminder Chauhan; Sirano Dhe-Paganon; Sara J Buhrlage
Journal:  Cell Chem Biol       Date:  2017-10-19       Impact factor: 8.116

5.  USP14 regulates DNA damage repair by targeting RNF168-dependent ubiquitination.

Authors:  Arishya Sharma; Turkeya Alswillah; Kamini Singh; Payel Chatterjee; Belinda Willard; Monica Venere; Matthew K Summers; Alexandru Almasan
Journal:  Autophagy       Date:  2018-08-10       Impact factor: 16.016

6.  Glioblastoma radiosensitization by pimozide.

Authors:  Barbara H Rath; Kevin Camphausen; Philip J Tofilon
Journal:  Transl Cancer Res       Date:  2016-11       Impact factor: 1.241

Review 7.  Breaking the chains: deubiquitylating enzyme specificity begets function.

Authors:  Michael J Clague; Sylvie Urbé; David Komander
Journal:  Nat Rev Mol Cell Biol       Date:  2019-06       Impact factor: 94.444

Review 8.  Advances in the Development Ubiquitin-Specific Peptidase (USP) Inhibitors.

Authors:  Shiyao Chen; Yunqi Liu; Huchen Zhou
Journal:  Int J Mol Sci       Date:  2021-04-27       Impact factor: 5.923

Review 9.  Regulation of the cell cycle and centrosome biology by deubiquitylases.

Authors:  Sarah Darling; Andrew B Fielding; Dorota Sabat-Pośpiech; Ian A Prior; Judy M Coulson
Journal:  Biochem Soc Trans       Date:  2017-09-12       Impact factor: 5.407

10.  The deubiquitinating enzyme USP5 promotes pancreatic cancer via modulating cell cycle regulators.

Authors:  Brajesh P Kaistha; Anja Krattenmacher; Johannes Fredebohm; Harald Schmidt; Diana Behrens; Miriam Widder; Thilo Hackert; Oliver Strobel; Jörg D Hoheisel; Thomas M Gress; Malte Buchholz
Journal:  Oncotarget       Date:  2017-08-03
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