| Literature DB >> 26639088 |
Yong Ryoul Yang1, Du-Seock Kang1, Cheol Lee1, Heon Seok2, Matilde Y Follo3, Lucio Cocco3, Pann-Ghill Suh4.
Abstract
In the brain, the primary phospholipase C (PLC) proteins, PLCβ, and PLCγ, are activated primarily by neurotransmitters, neurotrophic factors, and hormones through G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). Among the primary PLC isozymes, PLCβ1, PLCβ4, and PLCγ1 are highly expressed and differentially distributed, suggesting a specific role for each PLC subtype in different regions of the brain. Primary PLCs control neuronal activity, which is important for synapse function and development. In addition, dysregulation of primary PLC signaling is linked to several brain disorders including epilepsy, schizophrenia, bipolar disorder, Huntington's disease, depression and Alzheimer's disease. In this review, we included current knowledge regarding the roles of primary PLC isozymes in brain disorders.Entities:
Keywords: Brain disorder; PLCβ1; PLCβ4; PLCγ1; Phospholipase C
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Year: 2015 PMID： 26639088 DOI： 10.1016/j.jbior.2015.11.003
Source DB: PubMed Journal: Adv Biol Regul ISSN： 2212-4926