| Literature DB >> 26638077 |
Kathrin Reichwald1, Andreas Petzold1, Philipp Koch1, Bryan R Downie1, Nils Hartmann1, Stefan Pietsch1, Mario Baumgart1, Domitille Chalopin2, Marius Felder1, Martin Bens1, Arne Sahm1, Karol Szafranski1, Stefan Taudien1, Marco Groth1, Ivan Arisi3, Anja Weise4, Samarth S Bhatt4, Virag Sharma5, Johann M Kraus6, Florian Schmid7, Steffen Priebe8, Thomas Liehr4, Matthias Görlach1, Manuel E Than1, Michael Hiller5, Hans A Kestler9, Jean-Nicolas Volff2, Manfred Schartl10, Alessandro Cellerino11, Christoph Englert12, Matthias Platzer13.
Abstract
The killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in the laboratory. Its rapid growth, early sexual maturation, fast aging, and arrested embryonic development (diapause) make it an attractive model organism in biomedical research. Here, we report a draft sequence of its genome that allowed us to uncover an intra-species Y chromosome polymorphism representing-in real time-different stages of sex chromosome formation that display features of early mammalian XY evolution "in action." Our data suggest that gdf6Y, encoding a TGF-β family growth factor, is the master sex-determining gene in N. furzeri. Moreover, we observed genomic clustering of aging-related genes, identified genes under positive selection, and revealed significant similarities of gene expression profiles between diapause and aging, particularly for genes controlling cell cycle and translation. The annotated genome sequence is provided as an online resource (http://www.nothobranchius.info/NFINgb).Entities:
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Year: 2015 PMID： 26638077 DOI： 10.1016/j.cell.2015.10.071
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582