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Literature DB >> 26638028

Association between high expression macrophage migration inhibitory factor (MIF) alleles and West Nile virus encephalitis.

Rituparna Das¹, Kerry Loughran², Charles Murchison², Feng Qian², Lin Leng², Yan Song², Ruth R Montgomery³, Mark Loeb⁴, Richard Bucala².

Abstract

Infection with mosquito-borne West Nile virus (WNV) is usually asymptomatic but can lead to severe WNV encephalitis. The innate cytokine, macrophage migration inhibitory factor (MIF), is elevated in patients with WNV encephalitis and promotes viral neuroinvasion and mortality in animal models. In a case-control study, we examined functional polymorphisms in the MIF locus in a cohort of 454 North American patients with neuroinvasive WNV disease and found patients homozygous for high-expression MIF alleles to be >20-fold (p=0.008) more likely to have WNV encephalitis. These data indicate that MIF is an important determinant of severity of WNV neuropathogenesis and may be a therapeutic target.

Entities: Chemical Disease Gene Mutation Species

Keywords: Immune response; Macrophage; Mosquito vector; Neurologic disease; West Nile virus

Mesh：

Substances：

Year: 2015 PMID： 26638028 PMCID： PMC4696904 DOI： 10.1016/j.cyto.2015.11.021

Source DB: PubMed Journal: Cytokine ISSN： 1043-4666 Impact factor: 3.861

19 in total

1. Association of macrophage migration inhibitory factor (MIF) polymorphisms with risk of meningitis from Streptococcus pneumoniae.

Authors: Sarah Doernberg; Bernhard Schaaf; Klaus Dalhoff; Lin Leng; Anna Beitin; Vincent Quagliarello; Richard Bucala
Journal: Cytokine Date: 2011-01-03 Impact factor: 3.861

2. Macrophage Migration Inhibitory Factor Is Detrimental in Pneumococcal Pneumonia and a Target for Therapeutic Immunomodulation.

Authors: Jeffrey N Weiser; Aoife M Roche; Christopher B Hergott; Meredith I LaRose; Tarah Connolly; William L Jorgensen; Lin Leng; Richard Bucala; Rituparna Das
Journal: J Infect Dis Date: 2015-05-05 Impact factor: 5.226

3. CSF findings in 250 patients with serologically confirmed West Nile virus meningitis and encephalitis.

Authors: K L Tyler; J Pape; R J Goody; M Corkill; B K Kleinschmidt-DeMasters
Journal: Neurology Date: 2005-12-28 Impact factor: 9.910

4. Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection.

Authors: Imtiaz Yakub; Kristy M Lillibridge; Ana Moran; Omar Y Gonzalez; John Belmont; Richard A Gibbs; David J Tweardy
Journal: J Infect Dis Date: 2005-10-12 Impact factor: 5.226

5. Killer cell immunoglobulin-like receptor genes in four human West Nile virus infections reported 2011 in the Republic of Macedonia.

Authors: Mirko Spiroski; Zvonko Milenkovic; Aleksandar Petlichkovski; Ljubomir Ivanovski; Irena Kondova Topuzovska; Eli Djulejic
Journal: Hum Immunol Date: 2012-12-05 Impact factor: 2.850

6. A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis.

Authors: J A Baugh; S Chitnis; S C Donnelly; J Monteiro; X Lin; B J Plant; F Wolfe; P K Gregersen; R Bucala
Journal: Genes Immun Date: 2002-05 Impact factor: 2.676

7. Association between HLA class I and class II alleles and the outcome of West Nile virus infection: an exploratory study.

Authors: Marion C Lanteri; Zhanna Kaidarova; Trevor Peterson; Steven Cate; Brian Custer; Shiquan Wu; Maria Agapova; Jacqueline P Law; Thomas Bielawny; Frank Plummer; Leslie H Tobler; Mark Loeb; Michael P Busch; Jonathan Bramson; Ma Luo; Philip J Norris
Journal: PLoS One Date: 2011-08-01 Impact factor: 3.240

8. CCR5 deficiency increases risk of symptomatic West Nile virus infection.

Authors: William G Glass; David H McDermott; Jean K Lim; Sudkamon Lekhong; Shuk Fong Yu; William A Frank; John Pape; Ronald C Cheshier; Philip M Murphy
Journal: J Exp Med Date: 2006-01-17 Impact factor: 14.307

9. Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man.

Authors: Jean K Lim; Andrea Lisco; David H McDermott; Linda Huynh; Jerrold M Ward; Bernard Johnson; Hope Johnson; John Pape; Gregory A Foster; David Krysztof; Dean Follmann; Susan L Stramer; Leonid B Margolis; Philip M Murphy
Journal: PLoS Pathog Date: 2009-02-27 Impact factor: 6.823

10. Simultaneous detection of microsatellite repeats and SNPs in the macrophage migration inhibitory factor (MIF) gene by thin-film biosensor chips and application to rural field studies.

Authors: Xiao-bo Zhong; Lin Leng; Anna Beitin; Rui Chen; Courtney McDonald; Betty Hsiao; Robert D Jenison; Insoo Kang; Sung-Hwan Park; Annette Lee; Peter Gregersen; Philip Thuma; Patricia Bray-Ward; David C Ward; Richard Bucala
Journal: Nucleic Acids Res Date: 2005-08-02 Impact factor: 16.971

6 in total

1. MIF and D-DT are potential disease severity modifiers in male MS subjects.

Authors: Gil Benedek; Roberto Meza-Romero; Kelley Jordan; Ying Zhang; Ha Nguyen; Gail Kent; Jia Li; Edwin Siu; Jenny Frazer; Marta Piecychna; Xin Du; Antoine Sreih; Lin Leng; Jack Wiedrick; Stacy J Caillier; Halina Offner; Jorge R Oksenberg; Vijayshree Yadav; Dennis Bourdette; Richard Bucala; Arthur A Vandenbark
Journal: Proc Natl Acad Sci U S A Date: 2017-09-18 Impact factor: 11.205

Review 2. Age-related alterations in immune responses to West Nile virus infection.

Authors: R R Montgomery
Journal: Clin Exp Immunol Date: 2016-10-17 Impact factor: 4.330

3. Identification of genetic variants associated with dengue or West Nile virus disease: a systematic review and meta-analysis.

Authors: Megan E Cahill; Samantha Conley; Andrew T DeWan; Ruth R Montgomery
Journal: BMC Infect Dis Date: 2018-06-22 Impact factor: 3.090