Literature DB >> 26636491

SCFAs Take a Toll En Route to Metabolic Syndrome.

André Marette1, Christian Jobin2.   

Abstract

Gut dysbiosis is associated with development of metabolic syndrome in Tlr5(-/-) mice, but the underlying mechanism remains unclear. In this issue, Singh et al. (2015) report that augmented SCFA levels play a deleterious role in metabolic syndrome by promoting conversion of SFA to oleate in Tlr5(-/-) mice via increased liver SCD1expression.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26636491     DOI： 10.1016/j.cmet.2015.11.006

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  6 in total

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  6 in total

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