Literature DB >> 26634528

SET8 expression is associated with overall survival in gastric cancer.

X L Shi1, Z J Guo2, X L Wang3, X L Liu1, G F Shi4.   

Abstract

SET8, a member of the SET domain-containing methyl-transferase, has been implicated in various biological processes. In this study, SET8 was immunostained in 100 samples of gastric cancer tissues and semi-quantified using the HSCORE method to determine the predictive value of SET8 expression levels for gastric cancer outcome. The relationship between SET8 expression and the 5-year survival rate of gastric cancer patients was assessed. High expression of SET8 was associated with a shorter survival time in gastric cancer patients, and the level of SET8 expression was found to be an independent predictor of gastric cancer outcome (relative risk = 1.939; 95% confidence interval = 1.025-3.668; P = 0.042). Analysis of SET8 levels may help in the identification of patient subgroups that are at high risk for poor disease outcomes.

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Year:  2015        PMID： 26634528     DOI： 10.4238/2015.December.1.12

Source DB:  PubMed          Journal:  Genet Mol Res        ISSN： 1676-5680


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