Literature DB >> 26634025

Telomerase Therapy to Reverse Cardiovascular Senescence.

Timo Z Nazari-Shafti1, John P Cooke1.   

Abstract

Cellular senescence of endothelial cells plays an important role in the development of vascular lesions that ultimately lead to an atherosclerotic plaque. This review focuses on the age-related changes of endothelial and vascular smooth muscle cells that contribute to vascular disease and discusses potential new targets that could rejuvenate the vascular system and thereby prevent or delay atherosclerosis.

Entities:  

Keywords:  aging; atherosclerosis; cellular senescence; endothelium; modified MRNA; prevention; telomerase

Mesh：

Substances：

Year:  2015        PMID： 26634025      PMCID： PMC4666424          DOI： 10.14797/mdcj-11-3-172

Source DB:  PubMed          Journal:  Methodist Debakey Cardiovasc J        ISSN： 1947-6108


  33 in total

1.  Human telomerase reverse transcriptase is a promising target for cancer inhibition in squamous cell carcinomas.

Authors:  Young-Jin Park; Eun-Kyoung Kim; Sook Moon; Doo-Pyo Hong; Jung Yoon Bae; Jin Kim
Journal:  Anticancer Res       Date:  2014-11       Impact factor: 2.480

2.  Telomere attrition of the human abdominal aorta: relationships with age and atherosclerosis.

Authors:  K Okuda; M Y Khan; J Skurnick; M Kimura; H Aviv; A Aviv
Journal:  Atherosclerosis       Date:  2000-10       Impact factor: 5.162

3.  Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells.

Authors:  John Ramunas; Eduard Yakubov; Jennifer J Brady; Stéphane Y Corbel; Colin Holbrook; Moritz Brandt; Jonathan Stein; Juan G Santiago; John P Cooke; Helen M Blau
Journal:  FASEB J       Date:  2015-01-22       Impact factor: 5.191

4.  Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation.

Authors:  T Minamino; S A Mitsialis; S Kourembanas
Journal:  Mol Cell Biol       Date:  2001-05       Impact factor: 4.272

5.  Distribution of early atherosclerotic lesions in the human abdominal aorta correlates with wall shear stresses measured in vivo.

Authors:  E M Pedersen; S Oyre; M Agerbaek; I B Kristensen; S Ringgaard; P Boesiger; W P Paaske
Journal:  Eur J Vasc Endovasc Surg       Date:  1999-10       Impact factor: 7.069

6.  Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction.

Authors:  Tohru Minamino; Hideaki Miyauchi; Toshihiko Yoshida; Yasuo Ishida; Hideo Yoshida; Issei Komuro
Journal:  Circulation       Date:  2002-04-02       Impact factor: 29.690

7.  eNOS activity is reduced in senescent human endothelial cells: Preservation by hTERT immortalization.

Authors:  H Matsushita; E Chang; A J Glassford; J P Cooke; C P Chiu; P S Tsao
Journal:  Circ Res       Date:  2001-10-26       Impact factor: 17.367

Review 8.  Endothelial dysfunction, hemodynamic forces, and atherogenesis.

Authors:  M A Gimbrone; J N Topper; T Nagel; K R Anderson; G Garcia-Cardeña
Journal:  Ann N Y Acad Sci       Date:  2000-05       Impact factor: 5.691

Review 9.  How shelterin protects mammalian telomeres.

Authors:  Wilhelm Palm; Titia de Lange
Journal:  Annu Rev Genet       Date:  2008       Impact factor: 16.830

10.  Leukocyte telomere length is associated with measures of subclinical atherosclerosis.

Authors:  A G Panayiotou; A N Nicolaides; M Griffin; T Tyllis; N Georgiou; D Bond; R M Martin; D Hoppensteadt; J Fareed; S E Humphries
Journal:  Atherosclerosis       Date:  2010-02-04       Impact factor: 5.162
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  9 in total

Review 1.  Thrombospondin-1, Free Radicals, and the Coronary Microcirculation: The Aging Conundrum.

Authors:  Amanda J LeBlanc; Natia Q Kelm
Journal:  Antioxid Redox Signal       Date:  2017-09-08       Impact factor: 8.401

Review 2.  Aging-Induced Impairment of Vascular Function: Mitochondrial Redox Contributions and Physiological/Clinical Implications.

Authors:  Evan Paul Tracy; William Hughes; Jason E Beare; Gabrielle Rowe; Andreas Beyer; Amanda Jo LeBlanc
Journal:  Antioxid Redox Signal       Date:  2021-09-17       Impact factor: 7.468

3.  Thrombospondin-1 signaling through CD47 inhibits cell cycle progression and induces senescence in endothelial cells.

Authors:  Qi Gao; Kexin Chen; Lu Gao; Yang Zheng; Yong-Guang Yang
Journal:  Cell Death Dis       Date:  2016-09-08       Impact factor: 8.469

Review 4.  Aging: Molecular Pathways and Implications on the Cardiovascular System.

Authors:  Arthur José Pontes Oliveira de Almeida; Thaís Porto Ribeiro; Isac Almeida de Medeiros
Journal:  Oxid Med Cell Longev       Date:  2017-08-09       Impact factor: 6.543

5.  The Effects of Resistance Exercise With Blood Flow Restriction on Flow-Mediated Dilation and Arterial Stiffness in Elderly People With Low Gait Speed: Protocol for a Randomized Controlled Trial.

Authors:  Samuel Amorim; Hans Degens; Alexandra Passos Gaspar; Luciana Diniz Nagem Janot De Matos
Journal:  JMIR Res Protoc       Date:  2019-11-01

6.  Melatonin Alleviates Age-Associated Endothelial Injury of Atherosclerosis via Regulating Telomere Function.

Authors:  Yinghua Xie; Danfei Lou; Daimin Zhang
Journal:  J Inflamm Res       Date:  2021-12-11

7.  Bistability of Dielectrically Anisotropic Nematic Crystals and the Adaptation of Endothelial Collectives to Stress Fields.

Authors:  Georgios Stefopoulos; Tobias Lendenmann; Thomas M Schutzius; Costanza Giampietro; Tamal Roy; Nafsika Chala; Fabio Giavazzi; Roberto Cerbino; Dimos Poulikakos; Aldo Ferrari
Journal:  Adv Sci (Weinh)       Date:  2022-03-28       Impact factor: 17.521

Review 8.  Therapeutic Targeting of Telomerase.

Authors:  Kathrin Jäger; Michael Walter
Journal:  Genes (Basel)       Date:  2016-07-21       Impact factor: 4.096

9.  Effects of Lifestyle Modification on Telomerase Gene Expression in Hypertensive Patients: A Pilot Trial of Stress Reduction and Health Education Programs in African Americans.

Authors:  Shanthi Duraimani; Robert H Schneider; Otelio S Randall; Sanford I Nidich; Shichen Xu; Muluemebet Ketete; Maxwell A Rainforth; Carolyn Gaylord-King; John W Salerno; John Fagan
Journal:  PLoS One       Date:  2015-11-16       Impact factor: 3.240
  9 in total

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