| Literature DB >> 26632436 |
Zhiqiang Yu, Bo Yan, Liqian Gao, Chenbo Dong, Jian Zhong, Mathew D Ortenzio, Brandon Nguyen, Su Seong Lee, Xianglong Hu1, Feng Liang2.
Abstract
Despite being one of the most effective broad-spectrum chemotherapeutic agents in the treatment of cancers, the clinical applications of bleomycins (BLMs) have been limited due to their poor drug delivery abilities, and the side effect of causing lung fibrosis. With the increased therapeutics and the reduction of side effects, research and development of targeted drug delivery systems (TDDS) with BLMs have become essential for the expansive clinical usage of BLM-based therapeutics. This review summarizes the recent developments of various TDDS for BLMs, including techniques such as photochemical internalization, ultrasound, and micelle, liposome, and nanoparticle formation. The advantages and disadvantages for each delivery approach are outlined, along with the specific challenges associated with each delivery system.Entities:
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Year: 2016 PMID： 26632436 DOI： 10.2174/1568009616666151130213910
Source DB: PubMed Journal: Curr Cancer Drug Targets ISSN： 1568-0096 Impact factor: 3.428