Literature DB >> 26632062

Experimental observation of acoustic emissions generated by a pulsed proton beam from a hospital-based clinical cyclotron.

Kevin C Jones1, François Vander Stappen2, Christopher R Bawiec3, Guillaume Janssens2, Peter A Lewin3, Damien Prieels2, Timothy D Solberg1, Chandra M Sehgal4, Stephen Avery1.   

Abstract

PURPOSE: To measure the acoustic signal generated by a pulsed proton spill from a hospital-based clinical cyclotron.
METHODS: An electronic function generator modulated the IBA C230 isochronous cyclotron to create a pulsed proton beam. The acoustic emissions generated by the proton beam were measured in water using a hydrophone. The acoustic measurements were repeated with increasing proton current and increasing distance between detector and beam.
RESULTS: The cyclotron generated proton spills with rise times of 18 μs and a maximum measured instantaneous proton current of 790 nA. Acoustic emissions generated by the proton energy deposition were measured to be on the order of mPa. The origin of the acoustic wave was identified as the proton beam based on the correlation between acoustic emission arrival time and distance between the hydrophone and proton beam. The acoustic frequency spectrum peaked at 10 kHz, and the acoustic pressure amplitude increased monotonically with increasing proton current.
CONCLUSIONS: The authors report the first observation of acoustic emissions generated by a proton beam from a hospital-based clinical cyclotron. When modulated by an electronic function generator, the cyclotron is capable of creating proton spills with fast rise times (18 μs) and high instantaneous currents (790 nA). Measurements of the proton-generated acoustic emissions in a clinical setting may provide a method for in vivo proton range verification and patient monitoring.

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Year:  2015        PMID: 26632062     DOI: 10.1118/1.4935865

Source DB:  PubMed          Journal:  Med Phys        ISSN: 0094-2405            Impact factor:   4.071


  9 in total

1.  Acoustic-based proton range verification in heterogeneous tissue: simulation studies.

Authors:  Kevin C Jones; Wei Nie; James C H Chu; Julius V Turian; Alireza Kassaee; Chandra M Sehgal; Stephen Avery
Journal:  Phys Med Biol       Date:  2018-01-11       Impact factor: 3.609

2.  Proton range verification in homogeneous materials through acoustic measurements.

Authors:  Wei Nie; Kevin C Jones; Scott Petro; Alireza Kassaee; Chandra M Sehgal; Stephen Avery
Journal:  Phys Med Biol       Date:  2018-01-17       Impact factor: 3.609

Review 3.  In vivo range verification in particle therapy.

Authors:  Katia Parodi; Jerimy C Polf
Journal:  Med Phys       Date:  2018-11       Impact factor: 4.071

4.  The effects of Compton camera data acquisition and readout timing on PG imaging for proton range verification.

Authors:  Jerimy C Polf; Paul Maggi; Rajesh Panthi; Stephen Peterson; Dennis Mackin; Sam Beddar
Journal:  IEEE Trans Radiat Plasma Med Sci       Date:  2021-02-05

5.  Ionoacoustic tomography of the proton Bragg peak in combination with ultrasound and optoacoustic imaging.

Authors:  Stephan Kellnberger; Walter Assmann; Sebastian Lehrack; Sabine Reinhardt; Peter Thirolf; Daniel Queirós; George Sergiadis; Günther Dollinger; Katia Parodi; Vasilis Ntziachristos
Journal:  Sci Rep       Date:  2016-07-07       Impact factor: 4.379

6.  A novel range-verification method using ionoacoustic wave generated from spherical gold markers for particle-beam therapy: a simulation study.

Authors:  Taisuke Takayanagi; Tomoki Uesaka; Masanori Kitaoka; Mehmet Burcin Unlu; Kikuo Umegaki; Hiroki Shirato; Lei Xing; Taeko Matsuura
Journal:  Sci Rep       Date:  2019-03-08       Impact factor: 4.379

7.  On-line range verification for proton beam therapy using spherical ionoacoustic waves with resonant frequency.

Authors:  Taisuke Takayanagi; Tomoki Uesaka; Yuta Nakamura; Mehmet Burcin Unlu; Yasutoshi Kuriyama; Tomonori Uesugi; Yoshihiro Ishi; Nobuki Kudo; Masanori Kobayashi; Kikuo Umegaki; Satoshi Tomioka; Taeko Matsuura
Journal:  Sci Rep       Date:  2020-11-23       Impact factor: 4.379

8.  Initial Validation of Proton Dose Calculations on SPR Images from DECT in Treatment Planning System.

Authors:  Sina Mossahebi; Pouya Sabouri; Haijian Chen; Michelle Mundis; Matthew O'Neil; Paul Maggi; Jerimy C Polf
Journal:  Int J Part Ther       Date:  2020-11-23

9.  Enhancement of the ionoacoustic effect through ultrasound and photoacoustic contrast agents.

Authors:  Julie Lascaud; Pratik Dash; Matthias Würl; Hans-Peter Wieser; Benjamin Wollant; Ronaldo Kalunga; Walter Assmann; Dirk-André Clevert; Alfredo Ferrari; Paola Sala; Alessandro Stuart Savoia; Katia Parodi
Journal:  Sci Rep       Date:  2021-02-01       Impact factor: 4.379

  9 in total

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