Xiangmin Ding1, Ke Wang2, Zhengshan Wu2, Aihua Yao2, Jiaxin Li2, Chengyu Jiao2, Jianjun Qian3, Dousheng Bai3, Xiangcheng Li2. 1. Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health Nanjing 210029, China ; Department of Hepatopancreatobiliary Surgery, Subei People's Hospital Yangzhou 225000, China. 2. Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health Nanjing 210029, China. 3. Department of Hepatopancreatobiliary Surgery, Subei People's Hospital Yangzhou 225000, China.
Abstract
OBJECTIVE: Intrahepatic cholangiocarcinoma is a rare disease whose etiology is far from clear, the Ser326Cys polymorphism in human 8-hydroxyguanine glycosylase (hOGG1) has been shown associated with various cancers, however, the association of Ser326Cys (rsl052133) polymorphism and intrahepatic cholangiocarcinoma susceptibility has not been clarified. The purpose of this study is to investigate whether this polymorphism is related to the genetic susceptibility of intrahepatic cholangiocarcinoma. METHODS: A total 150 patients and 150 normal people were included in this study, the Ser326Cys polymorphisms in each group were genotyped using PCR-RFLP method. RESULTS: We found that individuals carrying Cys/Cys genotype were exposed to higher riskof intrahepatic cholangiocarcinoma (OR=2.924, 95% CI=1.475-5.780) compared with the individuals with wild type genotype Ser/Ser. Further analysis revealed that male individuals carrying Cys/Cys genotype also had increased risk (OR=2.762, 95% CI=1.233-6.173), whereas no significant difference was observed in female group. CONCLUSIONS: Therefore, our data indicates that the Ser326Cys (rs1052133) polymorphism is associated with intrahepatic cholangiocarcinoma susceptibility, and it shows preference in male population.
OBJECTIVE:Intrahepatic cholangiocarcinoma is a rare disease whose etiology is far from clear, the Ser326Cys polymorphism in human 8-hydroxyguanine glycosylase (hOGG1) has been shown associated with various cancers, however, the association of Ser326Cys (rsl052133) polymorphism and intrahepatic cholangiocarcinoma susceptibility has not been clarified. The purpose of this study is to investigate whether this polymorphism is related to the genetic susceptibility of intrahepatic cholangiocarcinoma. METHODS: A total 150 patients and 150 normal people were included in this study, the Ser326Cys polymorphisms in each group were genotyped using PCR-RFLP method. RESULTS: We found that individuals carrying Cys/Cys genotype were exposed to higher riskof intrahepatic cholangiocarcinoma (OR=2.924, 95% CI=1.475-5.780) compared with the individuals with wild type genotype Ser/Ser. Further analysis revealed that male individuals carrying Cys/Cys genotype also had increased risk (OR=2.762, 95% CI=1.233-6.173), whereas no significant difference was observed in female group. CONCLUSIONS: Therefore, our data indicates that the Ser326Cys (rs1052133) polymorphism is associated with intrahepatic cholangiocarcinoma susceptibility, and it shows preference in male population.
Authors: Juan Valle; Harpreet Wasan; Daniel H Palmer; David Cunningham; Alan Anthoney; Anthony Maraveyas; Srinivasan Madhusudan; Tim Iveson; Sharon Hughes; Stephen P Pereira; Michael Roughton; John Bridgewater Journal: N Engl J Med Date: 2010-04-08 Impact factor: 91.245
Authors: Harini Sampath; Vladimir Vartanian; M Rick Rollins; Kunihiko Sakumi; Yusaku Nakabeppu; R Stephen Lloyd Journal: PLoS One Date: 2012-12-17 Impact factor: 3.240
Authors: Ana Osorio; Roger L Milne; Karoline Kuchenbaecker; Tereza Vaclová; Guillermo Pita; Rosario Alonso; Paolo Peterlongo; Ignacio Blanco; Miguel de la Hoya; Mercedes Duran; Orland Díez; Teresa Ramón Y Cajal; Irene Konstantopoulou; Cristina Martínez-Bouzas; Raquel Andrés Conejero; Penny Soucy; Lesley McGuffog; Daniel Barrowdale; Andrew Lee; Brita Arver; Johanna Rantala; Niklas Loman; Hans Ehrencrona; Olufunmilayo I Olopade; Mary S Beattie; Susan M Domchek; Katherine Nathanson; Timothy R Rebbeck; Banu K Arun; Beth Y Karlan; Christine Walsh; Jenny Lester; Esther M John; Alice S Whittemore; Mary B Daly; Melissa Southey; John Hopper; Mary B Terry; Saundra S Buys; Ramunas Janavicius; Cecilia M Dorfling; Elizabeth J van Rensburg; Linda Steele; Susan L Neuhausen; Yuan Chun Ding; Thomas V O Hansen; Lars Jønson; Bent Ejlertsen; Anne-Marie Gerdes; Mar Infante; Belén Herráez; Leticia Thais Moreno; Jeffrey N Weitzel; Josef Herzog; Kisa Weeman; Siranoush Manoukian; Bernard Peissel; Daniela Zaffaroni; Giulietta Scuvera; Bernardo Bonanni; Frederique Mariette; Sara Volorio; Alessandra Viel; Liliana Varesco; Laura Papi; Laura Ottini; Maria Grazia Tibiletti; Paolo Radice; Drakoulis Yannoukakos; Judy Garber; Steve Ellis; Debra Frost; Radka Platte; Elena Fineberg; Gareth Evans; Fiona Lalloo; Louise Izatt; Ros Eeles; Julian Adlard; Rosemarie Davidson; Trevor Cole; Diana Eccles; Jackie Cook; Shirley Hodgson; Carole Brewer; Marc Tischkowitz; Fiona Douglas; Mary Porteous; Lucy Side; Lisa Walker; Patrick Morrison; Alan Donaldson; John Kennedy; Claire Foo; Andrew K Godwin; Rita Katharina Schmutzler; Barbara Wappenschmidt; Kerstin Rhiem; Christoph Engel; Alfons Meindl; Nina Ditsch; Norbert Arnold; Hans Jörg Plendl; Dieter Niederacher; Christian Sutter; Shan Wang-Gohrke; Doris Steinemann; Sabine Preisler-Adams; Karin Kast; Raymonda Varon-Mateeva; Andrea Gehrig; Dominique Stoppa-Lyonnet; Olga M Sinilnikova; Sylvie Mazoyer; Francesca Damiola; Bruce Poppe; Kathleen Claes; Marion Piedmonte; Kathy Tucker; Floor Backes; Gustavo Rodríguez; Wendy Brewster; Katie Wakeley; Thomas Rutherford; Trinidad Caldés; Heli Nevanlinna; Kristiina Aittomäki; Matti A Rookus; Theo A M van Os; Lizet van der Kolk; J L de Lange; Hanne E J Meijers-Heijboer; A H van der Hout; Christi J van Asperen; Encarna B Gómez Garcia; Nicoline Hoogerbrugge; J Margriet Collée; Carolien H M van Deurzen; Rob B van der Luijt; Peter Devilee; Edith Olah; Conxi Lázaro; Alex Teulé; Mireia Menéndez; Anna Jakubowska; Cezary Cybulski; Jacek Gronwald; Jan Lubinski; Katarzyna Durda; Katarzyna Jaworska-Bieniek; Oskar Th Johannsson; Christine Maugard; Marco Montagna; Silvia Tognazzo; Manuel R Teixeira; Sue Healey; Curtis Olswold; Lucia Guidugli; Noralane Lindor; Susan Slager; Csilla I Szabo; Joseph Vijai; Mark Robson; Noah Kauff; Liying Zhang; Rohini Rau-Murthy; Anneliese Fink-Retter; Christian F Singer; Christine Rappaport; Daphne Geschwantler Kaulich; Georg Pfeiler; Muy-Kheng Tea; Andreas Berger; Catherine M Phelan; Mark H Greene; Phuong L Mai; Flavio Lejbkowicz; Irene Andrulis; Anna Marie Mulligan; Gord Glendon; Amanda Ewart Toland; Anders Bojesen; Inge Sokilde Pedersen; Lone Sunde; Mads Thomassen; Torben A Kruse; Uffe Birk Jensen; Eitan Friedman; Yael Laitman; Shani Paluch Shimon; Jacques Simard; Douglas F Easton; Kenneth Offit; Fergus J Couch; Georgia Chenevix-Trench; Antonis C Antoniou; Javier Benitez Journal: PLoS Genet Date: 2014-04-03 Impact factor: 5.917