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Literature DB >> 26624236

Enantioselective Dehydrogenative Heck Arylations of Trisubstituted Alkenes with Indoles to Construct Quaternary Stereocenters.

Chun Zhang¹, Celine B Santiago¹, Jennifer M Crawford¹, Matthew S Sigman¹.

Abstract

An enantioselective, intermolecular dehydrogenative Heck arylation of trisubstituted alkenes to construct remote quaternary stereocenters has been developed. Using a new chiral pyridine oxazoline ligand, good to high enantioselectivity is achieved for various combinations of indole derivatives and trisubstituted alkenes. However, some combinations of substrates led to lower enantioselectivity, which provided the impetus to use structure enantioselectivity correlations to design a better performing ligand.

Entities: Chemical Gene

Mesh：

Substances：
Alkenes
Indoles
Hydrogen

Year: 2015 PMID： 26624236 PMCID： PMC5039010 DOI： 10.1021/jacs.5b11335

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

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