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Literature DB >> 266209

Host specificity of a serum marker for hepatitis B: evidence that "e antigen" has the properties of an immunoglobulin.

Abstract

A family of antigens, referred to collectively as e antigen (eAg), has been detected in sera of some individuals with liver disease who test positive for hepatitis B surface antigen. Studies on eAg partially purified by affinity chromatography on insolubilized antibodies to eAg revealed the following: (i) eAg has the physicochemical and immunologic properties of an immunoglobulin, predominantly of the IgG4 subclass, and (ii) specific antigenic sites, designated as e determinants, differentiate eAg from other immunoglobulins. We suggest that these determinants represent idiotypic determinants on antibodies that are formed in response to hepatitis B virus infection and that block the host's immune surveillance mechanisms by which virus proliferation is stopped.

Entities: Disease Gene

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Year: 1977 PMID： 266209 PMCID： PMC430861 DOI： 10.1073/pnas.74.4.1702

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

40 in total

10. Duality of hepatitis B e antigen in serum of persons infected with hepatitis B virus: evidence for the nonidentity of e antigen with immunoglobulins.

Authors: K Takahashi; M Imai; Y Miyakawa; S Iwakiri; M Mayumi
Journal: Proc Natl Acad Sci U S A Date: 1978-04 Impact factor: 11.205

Host specificity of a serum marker for hepatitis B: evidence that "e antigen" has the properties of an immunoglobulin.

1. The cleavage of human gamma-globulin by papain.

2. Observations on Australia antigen in Japanese.

3. Anti-e in primary hepatic carcinoma.

4. Identification of additional antigenic sites on Dane particles and the tubular forms of hepatitis B surface antigen.

5. Editorial: e: a third hepatitis B antigen?

6. Characterization of a new antigen-antibody system associated with hepatitis B.

7. Paraproteins with antibody activity in acute viral hepatitis and chronic autoimmune liver diseases.

8. Hepatitis B antigen: IgG components shown by immune electron microscopy.

9. Relation of e antigen to hepatitis B virus infection in an area of hyperendemicity.

10. A NEW CLASS OF HUMAN IMMUNOGLOBULINS. II. NORMAL SERUM IGD.

1. Progress with hepatitis B virus-editorial review.

2. Solid-phase radioimmunoassay for hepatitis Be antigen (HBeAg).

3. Viral hepatitis A and B in hemodialysed patients.

Review 4. The immunopathology of acute type B hepatitis.

5. Purification and partial characterization of hepatitis e antigen (HBeAg).

Review 6. The hepatitis B virus and its DNA polymerase: the prototype three-D virus.

7. IgG subclasses in circulating immune complexes with hepatitis B e antigen in chronic hepatitis B.

8. Hepatitis B e-antigen and its correlation with other serological markers in chimpanzees.

9. Changes in hepatitis B virus DNA polymerase in relation to the outcome of acute hepatitis type B.

10. Duality of hepatitis B e antigen in serum of persons infected with hepatitis B virus: evidence for the nonidentity of e antigen with immunoglobulins.