Literature DB >> 26620529

Conventional Matrices Loaded Onto a Graphene Layer Enhances MALDI-TOF/TOF Signal: Its Application to Improve Detection of Phosphorylated Peptides.

Carlos E Rodríguez1, Javier Palacios2, Ignacio Fajardo3,4, José Luis Urdiales3,4, Xavier Le Guével5, José Lozano3,6, Francisca Sánchez-Jiménez3,4.   

Abstract

This is the first study where graphene is used as a MALDI adjuvant in combination with the traditional matrix α-cyano-4-hydroxycinnamic acid (CHCA) to improve the signal intensity of peptide samples. Use of this amended matrix not only leads to increased signals but also to a higher number of peaks detected in complex samples. Additionally, the use of graphene has a stabilizing effect that can also be exploited to improve the detection of easily cleavable molecules. Graphical Abstract ᅟ.

Entities:  

Keywords:  Graphene; MALDI-TOF/TOF; Phosphorylated peptides

Mesh：

Substances：

Year:  2015        PMID： 26620529     DOI： 10.1007/s13361-015-1299-3

Source DB:  PubMed          Journal:  J Am Soc Mass Spectrom        ISSN： 1044-0305            Impact factor:   3.109


  9 in total

1.  Enrichment and detection of small molecules using magnetic graphene as an adsorbent and a novel matrix of MALDI-TOF-MS.

Authors:  Chenyi Shi; Jiaoran Meng; Chunhui Deng
Journal:  Chem Commun (Camb)       Date:  2012-01-25       Impact factor: 6.222

2.  Efficient analysis of non-polar environmental contaminants by MALDI-TOF MS with graphene as matrix.

Authors:  Jing Zhang; Xiaoli Dong; Jinsheng Cheng; Jinghong Li; Yinsheng Wang
Journal:  J Am Soc Mass Spectrom       Date:  2011-04-22       Impact factor: 3.109

3.  Graphene and graphene oxide: two ideal choices for the enrichment and ionization of long-chain fatty acids free from matrix-assisted laser desorption/ionization matrix interference.

Authors:  Yang Liu; Junyan Liu; Chunhui Deng; Xiangmin Zhang
Journal:  Rapid Commun Mass Spectrom       Date:  2011-11-15       Impact factor: 2.419

4.  High throughput identification of components from traditional Chinese medicine herbs by utilizing graphene or graphene oxide as MALDI-TOF-MS matrix.

Authors:  Yang Liu; Junyan Liu; Peng Yin; Mingxia Gao; Chunhui Deng; Xiangmin Zhang
Journal:  J Mass Spectrom       Date:  2011-08       Impact factor: 1.982

5.  High-Throughput and Rapid Screening of Low-Mass Hazardous Compounds in Complex Samples.

Authors:  Jing Wang; Qian Liu; Yan Gao; Yawei Wang; Liangqia Guo; Guibin Jiang
Journal:  Anal Chem       Date:  2015-06-11       Impact factor: 6.986

6.  Mildly oxidized graphene: facile synthesis, characterization, and application as a matrix in MALDI mass spectrometry.

Authors:  Qian Liu; Mengting Cheng; Guibin Jiang
Journal:  Chemistry       Date:  2013-03-12       Impact factor: 5.236

7.  Reduced graphene oxide films used as matrix of MALDI-TOF-MS for detection of octachlorodibenzo-p-dioxin.

Authors:  Xiaozhu Zhou; Yanyan Wei; Qiyuan He; Freddy Boey; Qichun Zhang; Hua Zhang
Journal:  Chem Commun (Camb)       Date:  2010-08-23       Impact factor: 6.222

8.  Graphene as a novel matrix for the analysis of small molecules by MALDI-TOF MS.

Authors:  Xiaoli Dong; Jinsheng Cheng; Jinghong Li; Yinsheng Wang
Journal:  Anal Chem       Date:  2010-07-15       Impact factor: 6.986

9.  A rapid and simple separation and direct detection of glutathione by gold nanoparticles and graphene-based MALDI-TOF-MS.

Authors:  Dan Wan; Mingxia Gao; Yuhua Wang; Peng Zhang; Xiangmin Zhang
Journal:  J Sep Sci       Date:  2012-12-26       Impact factor: 3.645
  9 in total
  4 in total

1.  Conformational Differentiation of α-Cyanohydroxycinnamic Acid Isomers: A Raman Spectroscopic Study.

Authors:  Jayson Vedad; Maciej E Domaradzki; Elmer-Rico E Mojica; Emmanuel J Chang; Adam A Profit; Ruel Z B Desamero
Journal:  J Raman Spectrosc       Date:  2017-07-27       Impact factor: 3.133

2.  Carbon Nanoparticles and Graphene Nanosheets as MALDI Matrices in Glycomics: a New Approach to Improve Glycan Profiling in Biological Samples.

Authors:  Alireza Banazadeh; Wenjing Peng; Lucas Veillon; Yehia Mechref
Journal:  J Am Soc Mass Spectrom       Date:  2018-06-18       Impact factor: 3.109

3.  A boronic acid modified binary matrix consisting of boron nitride and α-cyano-4-hydroxycinnamic acid for determination of cis-diols by MALDI-TOF MS.

Authors:  Ya-Shun Chen; Hua-Ming Xiao; Tian-Qi Wang; Lei Yu; Yu-Qi Feng
Journal:  Mikrochim Acta       Date:  2019-08-01       Impact factor: 5.833

4.  Large-Area Graphene Films as Target Surfaces for Highly Reproducible Matrix-Assisted Laser Desorption Ionization Suitable for Quantitative Mass Spectrometry.

Authors:  Yoon Kyung Choi; Joo Yeon Oh; Sang Yun Han
Journal:  J Am Soc Mass Spectrom       Date:  2018-07-11       Impact factor: 3.109
  4 in total

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