Literature DB >> 266190

Molecular properties of the nerve growth factor secreted by L cells.

N J Pantazis, M H Blanchard, B G Arnason, M Young.   

Abstract

The molecular size and stability of the nerve growth factor (NGF) secreted in culture by L cells have been studied by sedimentation and gel filtration chromatography. Results indicate that L cell NGF has a molecular weight of 160,000. It contains as part of its structure a protein component that is biologically, immunologically, and electrophoretically indistinguishable from the biologically active factor purified from mouse submandibular glands. However, unlike pure gland NGF, L cell NGF is highly stable in solution, and this finding indicates that L cell NGF is a form of the factor different from that previously described.

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Year:  1977        PMID： 266190      PMCID： PMC430813          DOI： 10.1073/pnas.74.4.1492

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  17 in total

1.  Molecular size of nerve growth factor in dilute solution.

Authors:  M Young; J D Saide; R A Murphy; B G Arnason
Journal:  J Biol Chem       Date:  1976-01-25       Impact factor: 5.157

2.  Amino acid sequences of mouse 2.5S nerve growth factor. II. Isolation and characterization of the thermolytic and peptic peptides and the complete covalent structure.

Authors:  R H Angeletti; M A Hermodson; R A Bradshaw
Journal:  Biochemistry       Date:  1973-01-02       Impact factor: 3.162

Review 3.  Nerve growth factor.

Authors:  R Levi-Montalcini; P U Angeletti
Journal:  Physiol Rev       Date:  1968-07       Impact factor: 37.312

4.  Synthesis and storage of a nerve growth protein in mouse submandibular glands.

Authors:  J A Burdman; M N Goldstein
Journal:  J Exp Zool       Date:  1965-11

Review 5.  Growth factors in mammalian cell culture.

Authors:  D Gospodarowicz; J S Moran
Journal:  Annu Rev Biochem       Date:  1976       Impact factor: 23.643

Review 6.  Nerve growth factor-recent developments and perspectives.

Authors:  R Bradshaw; M Young
Journal:  Biochem Pharmacol       Date:  1976-07-01       Impact factor: 5.858

7.  The nerve growth factor: purification as a 30,000-molecular-weight protein.

Authors:  V Bocchini; P U Angeletti
Journal:  Proc Natl Acad Sci U S A       Date:  1969-10       Impact factor: 11.205

8.  Synthesis of nerve growth factor by L and 3T3 cells in culture.

Authors:  J Oger; B G Arnason; N Pantazis; J Lehrich; M Young
Journal:  Proc Natl Acad Sci U S A       Date:  1974-04       Impact factor: 11.205

9.  Secretion of a nerve growth factor by mouse neuroblastoma cells in culture.

Authors:  R A Murphy; N J Pantazis; B G Arnason; M Young
Journal:  Proc Natl Acad Sci U S A       Date:  1975-05       Impact factor: 11.205

10.  Secretion of nerve growth factor by central nervous system glioma cells in culture.

Authors:  R A Murphy; J Oger; J D Saide; M H Blanchard; B G Arnason; C Hogan; N J Pantazis
Journal:  J Cell Biol       Date:  1977-03       Impact factor: 10.539
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  7 in total

1.  Synthesis and secretion of a high molecular weight form of nerve growth factor by skeletal muscle cells in culture.

Authors:  R A Murphy; R H Singer; J D Saide; N J Pantazis; M H Blanchard; K S Byron; B G Arnason; M Young
Journal:  Proc Natl Acad Sci U S A       Date:  1977-10       Impact factor: 11.205

2.  An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.

Authors:  R G Elgin; W H Busby; D R Clemmons
Journal:  Proc Natl Acad Sci U S A       Date:  1987-05       Impact factor: 11.205

Review 3.  The mouse submaxillary gland: a model for the study of hormonally dependent growth factors.

Authors:  P Walker
Journal:  J Endocrinol Invest       Date:  1982 May-Jun       Impact factor: 4.256

4.  De novo synthesis of NGF subunits in S-180 mouse sarcoma cell line.

Authors:  K Werrbach-Perez; J R Perez-Polo
Journal:  Neurochem Res       Date:  1987-10       Impact factor: 3.996

5.  Survival, morphology, and catecholamine storage of chromaffin cells in serum-free culture: evidence for a survival and differentiation promoting activity in medium conditioned by purified chromaffin cells.

Authors:  K Unsicker; G Stahnke; T H Müller
Journal:  Neurochem Res       Date:  1987-11       Impact factor: 3.996

6.  Molecular properties of the nerve growth factor secreted in mouse saliva.

Authors:  R A Murphy; J D Saide; M H Blanchard; M Young
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

7.  Immunocytochemical localization and concentrations of the alpha and gamma subunits of 7S-nerve growth factor in the submandibular gland of the mouse.

Authors:  M D Mowry; R J Jensen; N J Pantazis
Journal:  Cell Tissue Res       Date:  1984       Impact factor: 5.249
  7 in total

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