S Shenoi1, M L Shaffer2, C A Wallace1. 1. University of Washington School of Medicine and Seattle Children's Hospital and Research Institute, Seattle. 2. Seattle Children's Research Institute, Seattle, Washington.
Abstract
OBJECTIVE: Juvenile idiopathic arthritis (JIA) is a heterogeneous group of disorders characterized by chronic arthritis in children with unknown etiology. Although research evaluating environmental or early-life exposures in JIA is scarce, there are data to suggest that infections, smoking exposure, and lack of breastfeeding play a role. This case-control study investigated the association of selected environmental and early-life risk factors with the development of JIA. METHODS: JIA cases were identified at a major pediatric rheumatology outpatient clinic. Each case was asked to identify up to 3 healthy playmates of similar age and same sex to serve as controls. Parents/caregivers of cases and controls completed a questionnaire on selected environmental and early-life exposures. Conditional logistic regression adjusted for age and socioeconomic status was used to determine the odds ratio (OR) for developing JIA with 95% confidence intervals (95% CIs) for the playmate-matched design. RESULTS: Included in the study were 225 JIA cases and 138 controls. Compared to playmate-matched controls, preterm delivery (OR 1.8 [95% CI 1.2-2.7]) was associated with JIA. There was no association between JIA and household smoking or maternal prenatal smoking, breastfeeding, hospitalization with infection in the first year of life, daycare attendance before 6 years of age, household pets, or residential area prior to the onset of JIA. CONCLUSION: There was no association between the previously reported risk factors of smoking, early-life infection, or breastfeeding and development of JIA in this study. The association of preterm delivery with JIA needs to be further studied.
OBJECTIVE:Juvenile idiopathic arthritis (JIA) is a heterogeneous group of disorders characterized by chronic arthritis in children with unknown etiology. Although research evaluating environmental or early-life exposures in JIA is scarce, there are data to suggest that infections, smoking exposure, and lack of breastfeeding play a role. This case-control study investigated the association of selected environmental and early-life risk factors with the development of JIA. METHODS: JIA cases were identified at a major pediatric rheumatology outpatient clinic. Each case was asked to identify up to 3 healthy playmates of similar age and same sex to serve as controls. Parents/caregivers of cases and controls completed a questionnaire on selected environmental and early-life exposures. Conditional logistic regression adjusted for age and socioeconomic status was used to determine the odds ratio (OR) for developing JIA with 95% confidence intervals (95% CIs) for the playmate-matched design. RESULTS: Included in the study were 225 JIA cases and 138 controls. Compared to playmate-matched controls, preterm delivery (OR 1.8 [95% CI 1.2-2.7]) was associated with JIA. There was no association between JIA and household smoking or maternal prenatal smoking, breastfeeding, hospitalization with infection in the first year of life, daycare attendance before 6 years of age, household pets, or residential area prior to the onset of JIA. CONCLUSION: There was no association between the previously reported risk factors of smoking, early-life infection, or breastfeeding and development of JIA in this study. The association of preterm delivery with JIA needs to be further studied.
Authors: Ross E Petty; Taunton R Southwood; Prudence Manners; John Baum; David N Glass; Jose Goldenberg; Xiaohu He; Jose Maldonado-Cocco; Javier Orozco-Alcala; Anne-Marie Prieur; Maria E Suarez-Almazor; Patricia Woo Journal: J Rheumatol Date: 2004-02 Impact factor: 4.666
Authors: Paul A Harris; Robert Taylor; Robert Thielke; Jonathon Payne; Nathaniel Gonzalez; Jose G Conde Journal: J Biomed Inform Date: 2008-09-30 Impact factor: 6.317
Authors: Leena Suleiman; Emmanuelle Waubant; Gregory Aaen; Anita Belman; Leslie Benson; Meghan Candee; Tanuja Chitnis; Mark Gorman; Manu Goyal; Benjamin Greenberg; Yolanda Harris; Janace Hart; Ilana Kahn; Lauren Krupp; Timothy Lotze; Soe Mar; Manikum Moodley; Jayne Ness; Bardia Nourbakhsh; Mary Rensel; Moses Rodriguez; John Rose; Jennifer Rubin; Teri Schreiner; Jan-Mendelt Tillema; Amy Waldman; Bianca Weinstock-Guttman; T Charles Casper; Michael Waltz; Jennifer S Graves Journal: Mult Scler Relat Disord Date: 2018-03-26 Impact factor: 4.339
Authors: Francisco Airton Castro Rocha; Joaquim Ivo Vasques Dantas Landim; Mariana Lima Nour; Valdenir Freire Peixoto Filho; Leila Nascimento da Rocha; Marco Felipe Castro da Silva; Hermano Alexandre Lima Rocha Journal: Clin Rheumatol Date: 2019-05-06 Impact factor: 2.980
Authors: Francisco Airton Castro Rocha; Joaquim Ivo Vasques Dantas Landim; Marcela Gondim Aguiar; João Pedro Emrich Accioly; Carolina Noronha Lechiu; Luiza Helena Acácio Costa; Carlos Nobre Rabelo Júnior; Leila Nascimento da Rocha; Hermano Alexandre Lima Rocha Journal: Rheumatol Int Date: 2018-08-13 Impact factor: 2.631
Authors: Sarah L N Clarke; Katie S Mageean; Ilaria Maccora; Sean Harrison; Gabriele Simonini; Gemma C Sharp; Caroline L Relton; Athimalaipet V Ramanan Journal: Rheumatology (Oxford) Date: 2022-02-02 Impact factor: 7.580