Myong Kim1, Woo Suk Choi2, Chang Wook Jeong2, Ja Hyeon Ku2, Hyeon Hoe Kim2, Kyung Chul Moon3, Cheol Kwak2. 1. Department of Urology, Asan Medical Center Seoul, Republic of Korea. 2. Department of Urology, Seoul National University Hospital Seoul, Republic of Korea. 3. Department of Pathology, Seoul National University Hospital Seoul, Republic of Korea.
Abstract
OBJECTIVES: To evaluate the status of peritumoral pseudocapsules in renal tumors and the effects of clinicopathological factors on their formation. METHODS: From January 2011 to December 2012, 258 patients with solitary clinical stage T1a renal tumors who underwent partial nephrectomy were analyzed. Status of pseudocapsule was re-evaluated by a pathologist. RESULTS: The mean long diameter (± SD) of the tumor and the width of the safety margin were 2.17 (± 0.94) cm and 3.2 (± 2.4) mm, respectively. A complete pseudocapsule was identified in 152 (58.9%) tumors, an incomplete pseudocapsule was identified in 69 (26.7%) tumors, and no pseudocapsule was identified in 37 (14.3%) tumors. Out of 152 tumors with complete pseudocapsules, 45 (29.6%) were confirmed to directly invade the renal parenchyma. In a multivariable analysis, age (odds ratio [OR], 1.045; 95% confidence interval [CI], 1.021-1.070, P < 0.001) and histologic subtype (chromophobe type: OR, 19.455; 95% CI, 4.233-89.471, P < 0.001; oncocytoma: OR, 11.307; 95% CI, 1.357-94.198, P = 0.025) were significant factors for an incomplete or absent pseudocapsule. CONCLUSIONS: Peritumoral pseudocapsules are absent or incomplete in a significant portion of renal tumors. Old age as well as chromophobe and oncocytoma histologic subtypes were significant risk factors for an incomplete or absent peritumoral pseudocapsule.
OBJECTIVES: To evaluate the status of peritumoral pseudocapsules in renal tumors and the effects of clinicopathological factors on their formation. METHODS: From January 2011 to December 2012, 258 patients with solitary clinical stage T1a renal tumors who underwent partial nephrectomy were analyzed. Status of pseudocapsule was re-evaluated by a pathologist. RESULTS: The mean long diameter (± SD) of the tumor and the width of the safety margin were 2.17 (± 0.94) cm and 3.2 (± 2.4) mm, respectively. A complete pseudocapsule was identified in 152 (58.9%) tumors, an incomplete pseudocapsule was identified in 69 (26.7%) tumors, and no pseudocapsule was identified in 37 (14.3%) tumors. Out of 152 tumors with complete pseudocapsules, 45 (29.6%) were confirmed to directly invade the renal parenchyma. In a multivariable analysis, age (odds ratio [OR], 1.045; 95% confidence interval [CI], 1.021-1.070, P < 0.001) and histologic subtype (chromophobe type: OR, 19.455; 95% CI, 4.233-89.471, P < 0.001; oncocytoma: OR, 11.307; 95% CI, 1.357-94.198, P = 0.025) were significant factors for an incomplete or absent pseudocapsule. CONCLUSIONS: Peritumoral pseudocapsules are absent or incomplete in a significant portion of renal tumors. Old age as well as chromophobe and oncocytoma histologic subtypes were significant risk factors for an incomplete or absent peritumoral pseudocapsule.
Authors: Y Yamashita; M Takahashi; O Watanabe; S Yoshimatsu; S Ueno; S Ishimaru; M Kan; S Takano; N Ninomiya Journal: Radiology Date: 1992-08 Impact factor: 11.105
Authors: Borje Ljungberg; Karim Bensalah; Steven Canfield; Saeed Dabestani; Fabian Hofmann; Milan Hora; Markus A Kuczyk; Thomas Lam; Lorenzo Marconi; Axel S Merseburger; Peter Mulders; Thomas Powles; Michael Staehler; Alessandro Volpe; Axel Bex Journal: Eur Urol Date: 2015-01-21 Impact factor: 20.096
Authors: Bradley C Leibovich; Michael L Blute; John C Cheville; Christine M Lohse; Amy L Weaver; Horst Zincke Journal: J Urol Date: 2004-03 Impact factor: 7.450
Authors: Margaret F Meagher; Brian R Lane; Umberto Capitanio; Reza Mehrazin; Aaron W Bradshaw; Sabrina Noyes; Alessandro Larcher; Ahmed Eldefrawy; Fady Ghali; Devin Patel; Jacob Bruinius; Raksha Dutt; Cathrine Keiner; Nathan Miller; Fang Wan; Francesco Montorsi; Ithaar H Derweesh Journal: World J Urol Date: 2020-06-17 Impact factor: 4.226