| Literature DB >> 26616242 |
Kevin Titeca1,2, Pieter Meysman3,4, Kris Gevaert1,2, Jan Tavernier1,2, Kris Laukens3,4, Lennart Martens1,2,5, Sven Eyckerman1,2.
Abstract
Affinity purification-mass spectrometry is one of the most common techniques for the analysis of protein-protein interactions, but inferring bona fide interactions from the resulting data sets remains notoriously difficult. We introduce SFINX, a Straightforward Filtering INdeX that identifies true-positive protein interactions in a fast, user-friendly, and highly accurate way. SFINX outperforms alternative techniques on two benchmark data sets and is available via the Web interface at http://sfinx.ugent.be/.Keywords: affinity purification−mass spectrometry; interaction detection; interaction filtering; interactomics; protein−protein interactions
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Year: 2015 PMID： 26616242 DOI： 10.1021/acs.jproteome.5b00666
Source DB: PubMed Journal: J Proteome Res ISSN： 1535-3893 Impact factor: 4.466