| Literature DB >> 26611778 |
Paul T Cantey1, Jessica Weeks2, Morven Edwards3, Suchitra Rao4, G Amin Ostovar5, Walter Dehority6, Maria Alzona7, Sara Swoboda2, Brooke Christiaens8, Wassim Ballan8, John Hartley8, Andrew Terranella2, Jill Weatherhead3, James J Dunn3, Douglas P Marx3, M John Hicks3, Ronald A Rauch3, Christiana Smith4, Megan K Dishop9, Michael H Handler4, Roy W R Dudley10, Kote Chundu5, Dan Hobohm5, Iman Feiz-Erfan5, Joseph Hakes11, Ryan S Berry6, Shelly Stepensaski12, Benjamin Greenfield6, Laura Shroeder13, Henry Bishop1, Marcos de Almeida1, Blaine Mathison1, Mark Eberhard1.
Abstract
This case-series describes the 6 human infections with Onchocerca lupi, a parasite known to infect cats and dogs, that have been identified in the United States since 2013. Unlike cases reported outside the country, the American patients have not had subconjunctival nodules but have manifested more invasive disease (eg, spinal, orbital, and subdermal nodules). Diagnosis remains challenging in the absence of a serologic test. Treatment should be guided by what is done for Onchocerca volvulus as there are no data for O. lupi. Available evidence suggests that there may be transmission in southwestern United States, but the risk of transmission to humans is not known. Research is needed to better define the burden of disease in the United States and develop appropriately-targeted prevention strategies. Published by Oxford University Press for the Infectious Diseases Society of America 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.Entities:
Keywords: Onchocerca lupi; emerging infectious diseases; zoonotic infection
Mesh：
Year: 2015 PMID： 26611778 PMCID： PMC4809994 DOI： 10.1093/cid/civ983
Source DB: PubMed Journal: Clin Infect Dis ISSN： 1058-4838 Impact factor: 9.079