Literature DB >> 26611589

MRI-Guided Delivery of Viral Vectors.

Ernesto A Salegio1,2, John Bringas1, Krystof S Bankiewicz3.   

Abstract

Gene therapy has emerged as a potential avenue of treatment for many neurological disorders. Technological advances in imaging techniques allow for the monitoring of real-time infusions into the brain of rodents, nonhuman primates, and humans. Here, we discuss the use of magnetic resonance imaging (MRI) as a tool in the delivery of adeno-associated viral (AAV) particles into brain of nonhuman primates.

Entities:  

Keywords:  AAV; Gene therapy; MRI; Nonhuman primates; Preclinical

Mesh:

Year:  2016        PMID: 26611589     DOI: 10.1007/978-1-4939-3271-9_15

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN: 1064-3745


  5 in total

Review 1.  Chemogenetics as a neuromodulatory approach to treating neuropsychiatric diseases and disorders.

Authors:  Jingwei Song; Ruchit V Patel; Massoud Sharif; Anagha Ashokan; Michael Michaelides
Journal:  Mol Ther       Date:  2021-12-01       Impact factor: 11.454

2.  MR-guided parenchymal delivery of adeno-associated viral vector serotype 5 in non-human primate brain.

Authors:  L Samaranch; B Blits; W San Sebastian; P Hadaczek; J Bringas; V Sudhakar; M Macayan; P J Pivirotto; H Petry; K S Bankiewicz
Journal:  Gene Ther       Date:  2017-03-16       Impact factor: 5.250

3.  MR-guided delivery of AAV2-BDNF into the entorhinal cortex of non-human primates.

Authors:  Alan H Nagahara; Bayard R Wilson; Iryna Ivasyk; Imre Kovacs; Saytam Rawalji; John R Bringas; Phillip J Pivirotto; Waldy San Sebastian; Lluis Samaranch; Krystof S Bankiewicz; Mark H Tuszynski
Journal:  Gene Ther       Date:  2018-03-13       Impact factor: 5.250

4.  Design and Validation of a Multi-Point Injection Technology for MR-Guided Convection Enhanced Delivery in the Brain.

Authors:  Kayla Prezelski; Megan Keiser; Joel M Stein; Timothy H Lucas; Beverly Davidson; Pedro Gonzalez-Alegre; Flavia Vitale
Journal:  Front Med Technol       Date:  2021-10-14

Review 5.  Induced Pluripotent Stem Cells (iPSCs) and Gene Therapy: A New Era for the Treatment of Neurological Diseases.

Authors:  Giulia Paolini Sguazzi; Valentina Muto; Marco Tartaglia; Enrico Bertini; Claudia Compagnucci
Journal:  Int J Mol Sci       Date:  2021-12-20       Impact factor: 5.923

  5 in total

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