Literature DB >> 34861415

Chemogenetics as a neuromodulatory approach to treating neuropsychiatric diseases and disorders.

Jingwei Song1, Ruchit V Patel2, Massoud Sharif3, Anagha Ashokan3, Michael Michaelides4.   

Abstract

Chemogenetics enables precise, non-invasive, and reversible modulation of neural activity via the activation of engineered receptors that are pharmacologically selective to endogenous or exogenous ligands. With recent advances in therapeutic gene delivery, chemogenetics is poised to support novel interventions against neuropsychiatric diseases and disorders. To evaluate its translational potential, we performed a scoping review of applications of chemogenetics that led to the reversal of molecular and behavioral deficits in studies relevant to neuropsychiatric diseases and disorders. In this review, we present these findings and discuss the potential and challenges for using chemogenetics as a precision medicine-based neuromodulation strategy.
Copyright © 2021 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  DREADDs; chemogenetics; gene delivery; gene therapy; neuromodulation; neurotherapeutics

Mesh：

Substances：

Year:  2021        PMID： 34861415      PMCID： PMC8899595          DOI： 10.1016/j.ymthe.2021.11.019

Source DB:  PubMed          Journal:  Mol Ther        ISSN： 1525-0016            Impact factor:   11.454


  197 in total

1.  Dynorphin-kappa opioid receptor activity in the central amygdala modulates binge-like alcohol drinking in mice.

Authors:  Rachel I Anderson; Marcelo F Lopez; William C Griffin; Harold L Haun; Daniel W Bloodgood; Dipanwita Pati; Kristen M Boyt; Thomas L Kash; Howard C Becker
Journal:  Neuropsychopharmacology       Date:  2018-12-11       Impact factor: 7.853

2.  Long-term chemogenetic suppression of spontaneous seizures in a mouse model for temporal lobe epilepsy.

Authors:  Jana Desloovere; Paul Boon; Lars E Larsen; Caroline Merckx; Marie-Gabrielle Goossens; Chris Van den Haute; Veerle Baekelandt; Dimitri De Bundel; Evelien Carrette; Jean Delbeke; Alfred Meurs; Kristl Vonck; Wytse Wadman; Robrecht Raedt
Journal:  Epilepsia       Date:  2019-10-13       Impact factor: 5.864

3.  Cholinergic Interneurons Amplify Thalamostriatal Excitation of Striatal Indirect Pathway Neurons in Parkinson's Disease Models.

Authors:  Asami Tanimura; Yijuan Du; Jyothisri Kondapalli; David L Wokosin; D James Surmeier
Journal:  Neuron       Date:  2019-01-15       Impact factor: 17.173

4.  Development of hydrocephalus in mice expressing the G(i)-coupled GPCR Ro1 RASSL receptor in astrocytes.

Authors:  Elizabeth J Sweger; Kristen B Casper; Kimberly Scearce-Levie; Bruce R Conklin; Ken D McCarthy
Journal:  J Neurosci       Date:  2007-02-28       Impact factor: 6.167

5.  Chronic activation of hypothalamic oxytocin neurons improves cardiac function during left ventricular hypertrophy-induced heart failure.

Authors:  Kara Garrott; Jhansi Dyavanapalli; Edmund Cauley; Mary Kate Dwyer; Sarah Kuzmiak-Glancy; Xin Wang; David Mendelowitz; Matthew W Kay
Journal:  Cardiovasc Res       Date:  2017-09-01       Impact factor: 10.787

6.  Cell-type specific regulation of cortical excitability through the allatostatin receptor system.

Authors:  Taruna Ikrar; Yulin Shi; Tomoko Velasquez; Martyn Goulding; Xiangmin Xu
Journal:  Front Neural Circuits       Date:  2012-01-20       Impact factor: 3.492

7.  MR-guided parenchymal delivery of adeno-associated viral vector serotype 5 in non-human primate brain.

Authors:  L Samaranch; B Blits; W San Sebastian; P Hadaczek; J Bringas; V Sudhakar; M Macayan; P J Pivirotto; H Petry; K S Bankiewicz
Journal:  Gene Ther       Date:  2017-03-16       Impact factor: 5.250

8.  Behavioral Effects of Acute Systemic Low-Dose Clozapine in Wild-Type Rats: Implications for the Use of DREADDs in Behavioral Neuroscience.

Authors:  Ann-Kathrin Ilg; Thomas Enkel; Dusan Bartsch; Florian Bähner
Journal:  Front Behav Neurosci       Date:  2018-08-14       Impact factor: 3.558

9.  Chemical-genetic attenuation of focal neocortical seizures.

Authors:  Dennis Kätzel; Elizabeth Nicholson; Stephanie Schorge; Matthew C Walker; Dimitri M Kullmann
Journal:  Nat Commun       Date:  2014-05-27       Impact factor: 14.919

10.  DREADD Activation of Pedunculopontine Cholinergic Neurons Reverses Motor Deficits and Restores Striatal Dopamine Signaling in Parkinsonian Rats.

Authors:  Puneet K Sharma; Lisa Wells; Gaia Rizzo; Joanna L Elson; Jan Passchier; Eugenii A Rabiner; Roger N Gunn; David T Dexter; Ilse S Pienaar
Journal:  Neurotherapeutics       Date:  2020-07       Impact factor: 6.088
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  2 in total

Review 1.  Alteration of Neural Pathways and Its Implications in Alzheimer's Disease.

Authors:  Sujin Kim; Yunkwon Nam; Hyeon Soo Kim; Haram Jung; Seong Gak Jeon; Sang Bum Hong; Minho Moon
Journal:  Biomedicines       Date:  2022-04-04

2.  The long non-coding RNA LIMT inhibits metastasis of hepatocellular carcinoma and is suppressed by EGF signaling.

Authors:  Yu Hu; Hao Li; Hongwei Zhang; Qiang Tang; Guangtan Zhang; Xiqing Li; Fei Xue
Journal:  Mol Biol Rep       Date:  2022-05-08       Impact factor: 2.742
  2 in total

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