Literature DB >> 26606658

Adeno-associated Vector Toxicity-To Be or Not to Be?

Hildegard Büning1, Manfred Schmidt1.   

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Year:  2015        PMID： 26606658      PMCID： PMC4817949          DOI： 10.1038/mt.2015.182

Source DB:  PubMed          Journal:  Mol Ther        ISSN： 1525-0016            Impact factor:   11.454


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  23 in total

1.  Role of viral vectors and virion shells in cellular gene expression.

Authors:  Jackie L Stilwell; Richard Jude Samulski
Journal:  Mol Ther       Date:  2004-03       Impact factor: 11.454

2.  A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication.

Authors:  R J Samulski; L S Chang; T Shenk
Journal:  J Virol       Date:  1987-10       Impact factor: 5.103

3.  Large-scale molecular characterization of adeno-associated virus vector integration in mouse liver.

Authors:  Hiroyuki Nakai; Xiaolin Wu; Sally Fuess; Theresa A Storm; David Munroe; Eugenio Montini; Shawn M Burgess; Markus Grompe; Mark A Kay
Journal:  J Virol       Date:  2005-03       Impact factor: 5.103

Review 4.  Adeno-associated virus at 50: a golden anniversary of discovery, research, and gene therapy success--a personal perspective.

Authors:  Eric Hastie; R Jude Samulski
Journal:  Hum Gene Ther       Date:  2015-04-20       Impact factor: 5.695

5.  Molecular detection of adeno-associated virus in cases of spontaneous and intentional human abortion.

Authors:  Christiane Curi Pereira; Luciana Bueno de Freitas; Paulo Roberto Merçon de Vargas; Maria Luiza Borges de Azevedo; Jussara Pereira do Nascimento; Liliana Cruz Spano
Journal:  J Med Virol       Date:  2010-10       Impact factor: 2.327

6.  Large-scale analysis of adeno-associated virus vector integration sites in normal human cells.

Authors:  Daniel G Miller; Grant D Trobridge; Lisa M Petek; Michael A Jacobs; Rajinder Kaul; David W Russell
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

7.  AAV serotype 2 vectors preferentially integrate into active genes in mice.

Authors:  Hiroyuki Nakai; Eugenio Montini; Sally Fuess; Theresa A Storm; Markus Grompe; Mark A Kay
Journal:  Nat Genet       Date:  2003-07       Impact factor: 38.330

8.  Adeno-associated virus vectors integrate at chromosome breakage sites.

Authors:  Daniel G Miller; Lisa M Petek; David W Russell
Journal:  Nat Genet       Date:  2004-06-20       Impact factor: 38.330

9.  Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas.

Authors:  Jean-Charles Nault; Shalini Datta; Sandrine Imbeaud; Andrea Franconi; Maxime Mallet; Gabrielle Couchy; Eric Letouzé; Camilla Pilati; Benjamin Verret; Jean-Frédéric Blanc; Charles Balabaud; Julien Calderaro; Alexis Laurent; Mélanie Letexier; Paulette Bioulac-Sage; Fabien Calvo; Jessica Zucman-Rossi
Journal:  Nat Genet       Date:  2015-08-24       Impact factor: 38.330

10.  Clades of Adeno-associated viruses are widely disseminated in human tissues.

Authors:  Guangping Gao; Luk H Vandenberghe; Mauricio R Alvira; You Lu; Roberto Calcedo; Xiangyang Zhou; James M Wilson
Journal:  J Virol       Date:  2004-06       Impact factor: 5.103
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  28 in total

1.  Wild-type AAV Insertions in Hepatocellular Carcinoma Do Not Inform Debate Over Genotoxicity Risk of Vectorized AAV.

Authors:  Jean-Charles Nault; Iadh Mami; Tiziana La Bella; Shalini Datta; Sandrine Imbeaud; Andrea Franconi; Maxime Mallet; Gabrielle Couchy; Eric Letouzé; Camilla Pilati; Benjamin Verret; Jean-Frédéric Blanc; Charles Balabaud; Julien Calderaro; Alexis Laurent; Mélanie Letexier; Paulette Bioulac-Sage; Fabien Calvo; Jessica Zucman-Rossi
Journal:  Mol Ther       Date:  2016-04       Impact factor: 11.454

2.  Reply to "Wild-type AAV Insertions in Hepatocellular Carcinoma Do Not Inform Debate Over Genotoxicity Risk of Vectorized AAV".

Authors:  Manfred Schmidt; Irene Gil-Farina; Hildegard Büning
Journal:  Mol Ther       Date:  2016-04       Impact factor: 11.454

3.  Genotoxicity in Mice Following AAV Gene Delivery: A Safety Concern for Human Gene Therapy?

Authors:  Randy J Chandler; Matthew C LaFave; Gaurav K Varshney; Shawn M Burgess; Charles P Venditti
Journal:  Mol Ther       Date:  2016-02       Impact factor: 11.454

4.  Identification of liver-specific enhancer-promoter activity in the 3' untranslated region of the wild-type AAV2 genome.

Authors:  Grant J Logan; Allison P Dane; Claus V Hallwirth; Christine M Smyth; Emilie E Wilkie; Anais K Amaya; Erhua Zhu; Neeta Khandekar; Samantha L Ginn; Sophia H Y Liao; Sharon C Cunningham; Natsuki Sasaki; Martí Cabanes-Creus; Patrick P L Tam; David W Russell; Leszek Lisowski; Ian E Alexander
Journal:  Nat Genet       Date:  2017-06-19       Impact factor: 38.330

5.  AAV Infection: Protection from Cancer.

Authors:  Arun Srivastava; Barrie J Carter
Journal:  Hum Gene Ther       Date:  2016-11-10       Impact factor: 5.695

Review 6.  Evaluating the state of the science for adeno-associated virus integration: An integrated perspective.

Authors:  Denise E Sabatino; Frederic D Bushman; Randy J Chandler; Ronald G Crystal; Beverly L Davidson; Ricardo Dolmetsch; Kevin C Eggan; Guangping Gao; Irene Gil-Farina; Mark A Kay; Douglas M McCarty; Eugenio Montini; Adora Ndu; Jing Yuan
Journal:  Mol Ther       Date:  2022-06-10       Impact factor: 12.910

Review 7.  A Systematic Review and Meta-Analyses of Interventional Clinical Trial Studies for Gene Therapies for the Inherited Retinal Degenerations (IRDs).

Authors:  Gearóid P Tuohy; Roly Megaw
Journal:  Biomolecules       Date:  2021-05-19

8.  Recombinant AAV Integration Is Not Associated With Hepatic Genotoxicity in Nonhuman Primates and Patients.

Authors:  Irene Gil-Farina; Raffaele Fronza; Christine Kaeppel; Esperanza Lopez-Franco; Valerie Ferreira; Delia D'Avola; Alberto Benito; Jesus Prieto; Harald Petry; Gloria Gonzalez-Aseguinolaza; Manfred Schmidt
Journal:  Mol Ther       Date:  2016-03-07       Impact factor: 11.454

Review 9.  Cell and gene therapy strategies to eradicate HIV reservoirs.

Authors:  Chelsea Spragg; Harshana De Silva Feelixge; Keith R Jerome
Journal:  Curr Opin HIV AIDS       Date:  2016-07       Impact factor: 4.283

10.  AAV ablates neurogenesis in the adult murine hippocampus.

Authors:  Stephen Johnston; Sarah L Parylak; Stacy Kim; Nolan Mac; Christina Lim; Iryna Gallina; Cooper Bloyd; Alexander Newberry; Christian D Saavedra; Ondrej Novak; J Tiago Gonçalves; Fred H Gage; Matthew Shtrahman
Journal:  Elife       Date:  2021-07-14       Impact factor: 8.140
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