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Literature DB >> 27081717

Wild-type AAV Insertions in Hepatocellular Carcinoma Do Not Inform Debate Over Genotoxicity Risk of Vectorized AAV.

Jean-Charles Nault^1,2,3,4,5, Iadh Mami^1,2,3,4, Tiziana La Bella^1,2,3,4, Shalini Datta^1,2,3,4, Sandrine Imbeaud^1,2,3,4, Andrea Franconi^1,2,3,4, Maxime Mallet^1,2,3,4, Gabrielle Couchy^1,2,3,4, Eric Letouzé^1,2,3,4, Camilla Pilati^1,2,3,4, Benjamin Verret^1,4, Jean-Frédéric Blanc^6,7, Charles Balabaud⁷, Julien Calderaro^1,2,3,4,8, Alexis Laurent^9,10, Mélanie Letexier¹¹, Paulette Bioulac-Sage^7,12, Fabien Calvo^1,2,3,4,13, Jessica Zucman-Rossi^1,2,3,4,14.

Abstract

Entities: Disease

Mesh：

Year: 2016 PMID： 27081717 PMCID： PMC4886947 DOI： 10.1038/mt.2016.47

Source DB: PubMed Journal: Mol Ther ISSN： 1525-0016 Impact factor: 11.454

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8 in total

1. Adeno-associated Vector Toxicity-To Be or Not to Be?

Authors: Hildegard Büning; Manfred Schmidt
Journal: Mol Ther Date: 2015-11 Impact factor: 11.454

2. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma.

Authors: Wing-Kin Sung; Hancheng Zheng; Shuyu Li; Ronghua Chen; Xiao Liu; Yingrui Li; Nikki P Lee; Wah H Lee; Pramila N Ariyaratne; Chandana Tennakoon; Fabianus H Mulawadi; Kwong F Wong; Angela M Liu; Ronnie T Poon; Sheung Tat Fan; Kwong L Chan; Zhuolin Gong; Yujie Hu; Zhao Lin; Guan Wang; Qinghui Zhang; Thomas D Barber; Wen-Chi Chou; Amit Aggarwal; Ke Hao; Wei Zhou; Chunsheng Zhang; James Hardwick; Carolyn Buser; Jiangchun Xu; Zhengyan Kan; Hongyue Dai; Mao Mao; Christoph Reinhard; Jun Wang; John M Luk
Journal: Nat Genet Date: 2012-05-27 Impact factor: 38.330

3. Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy.

Authors: Randy J Chandler; Matthew C LaFave; Gaurav K Varshney; Niraj S Trivedi; Nuria Carrillo-Carrasco; Julien S Senac; Weiwei Wu; Victoria Hoffmann; Abdel G Elkahloun; Shawn M Burgess; Charles P Venditti
Journal: J Clin Invest Date: 2015-01-20 Impact factor: 14.808

4. Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas.

Authors: Jean-Charles Nault; Shalini Datta; Sandrine Imbeaud; Andrea Franconi; Maxime Mallet; Gabrielle Couchy; Eric Letouzé; Camilla Pilati; Benjamin Verret; Jean-Frédéric Blanc; Charles Balabaud; Julien Calderaro; Alexis Laurent; Mélanie Letexier; Paulette Bioulac-Sage; Fabien Calvo; Jessica Zucman-Rossi
Journal: Nat Genet Date: 2015-08-24 Impact factor: 38.330

5. AAV vector integration sites in mouse hepatocellular carcinoma.

Authors: Anthony Donsante; Daniel G Miller; Yi Li; Carole Vogler; Elizabeth M Brunt; David W Russell; Mark S Sands
Journal: Science Date: 2007-07-27 Impact factor: 47.728

6. Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene.

Authors: Patrizia Paterlini-Bréchot; Kenichi Saigo; Yoshiki Murakami; Mounia Chami; Devrim Gozuacik; Claude Mugnier; David Lagorce; Christian Bréchot
Journal: Oncogene Date: 2003-06-19 Impact factor: 9.867

7. Toward understanding and exploiting tumor heterogeneity.

Authors: Ash A Alizadeh; Victoria Aranda; Alberto Bardelli; Cedric Blanpain; Christoph Bock; Christine Borowski; Carlos Caldas; Andrea Califano; Michael Doherty; Markus Elsner; Manel Esteller; Rebecca Fitzgerald; Jan O Korbel; Peter Lichter; Christopher E Mason; Nicholas Navin; Dana Pe'er; Kornelia Polyak; Charles W M Roberts; Lillian Siu; Alexandra Snyder; Hannah Stower; Charles Swanton; Roel G W Verhaak; Jean C Zenklusen; Johannes Zuber; Jessica Zucman-Rossi
Journal: Nat Med Date: 2015-08 Impact factor: 53.440

8. Targeted integration of adeno-associated virus (AAV) into human chromosome 19.

Authors: R J Samulski; X Zhu; X Xiao; J D Brook; D E Housman; N Epstein; L A Hunter
Journal: EMBO J Date: 1991-12 Impact factor: 11.598

8 in total

15 in total

1. BAX 335 hemophilia B gene therapy clinical trial results: potential impact of CpG sequences on gene expression.

Authors: Barbara A Konkle; Christopher E Walsh; Miguel A Escobar; Neil C Josephson; Guy Young; Annette von Drygalski; Scott W J McPhee; R Jude Samulski; Ivan Bilic; Maurus de la Rosa; Birgit M Reipert; Hanspeter Rottensteiner; Friedrich Scheiflinger; John C Chapin; Bruce Ewenstein; Paul E Monahan
Journal: Blood Date: 2021-02-11 Impact factor: 22.113

2. Reply to "Wild-type AAV Insertions in Hepatocellular Carcinoma Do Not Inform Debate Over Genotoxicity Risk of Vectorized AAV".

Authors: Manfred Schmidt; Irene Gil-Farina; Hildegard Büning
Journal: Mol Ther Date: 2016-04 Impact factor: 11.454

3. Identification of liver-specific enhancer-promoter activity in the 3' untranslated region of the wild-type AAV2 genome.

Authors: Grant J Logan; Allison P Dane; Claus V Hallwirth; Christine M Smyth; Emilie E Wilkie; Anais K Amaya; Erhua Zhu; Neeta Khandekar; Samantha L Ginn; Sophia H Y Liao; Sharon C Cunningham; Natsuki Sasaki; Martí Cabanes-Creus; Patrick P L Tam; David W Russell; Leszek Lisowski; Ian E Alexander
Journal: Nat Genet Date: 2017-06-19 Impact factor: 38.330

Wild-type AAV Insertions in Hepatocellular Carcinoma Do Not Inform Debate Over Genotoxicity Risk of Vectorized AAV.

1. Adeno-associated Vector Toxicity-To Be or Not to Be?

2. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma.

3. Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy.

4. Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas.

5. AAV vector integration sites in mouse hepatocellular carcinoma.

6. Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene.

7. Toward understanding and exploiting tumor heterogeneity.

8. Targeted integration of adeno-associated virus (AAV) into human chromosome 19.

1. BAX 335 hemophilia B gene therapy clinical trial results: potential impact of CpG sequences on gene expression.

2. Reply to "Wild-type AAV Insertions in Hepatocellular Carcinoma Do Not Inform Debate Over Genotoxicity Risk of Vectorized AAV".

3. Identification of liver-specific enhancer-promoter activity in the 3' untranslated region of the wild-type AAV2 genome.

Review 4. Update on clinical gene therapy for hemophilia.

5. AAV Infection: Protection from Cancer.

Review 6. Cryo-electron Microscopy of Adeno-associated Virus.

Review 7. Genomics of Viral Hepatitis-Associated Liver Tumors.

Review 8. Emerging Issues in AAV-Mediated In Vivo Gene Therapy.

Review 9. The Evolution of Gene Therapy in the Treatment of Metabolic Liver Diseases.

10. Intramuscular Delivery of Gene Therapy for Targeting the Nervous System.