Literature DB >> 26606289

Water soluble heterometallic potassium-dioxidovanadium(V) complexes as potential antiproliferative agents.

Manas Sutradhar1, Alexandra R Fernandes2, Joana Silva3, Kamran T Mahmudov4, M Fátima C Guedes da Silva5, Armando J L Pombeiro6.   

Abstract

Two water soluble heterometallic potassium–dioxidovanadium polymers, [KVO2(L1)]n (1) and [KVO2(L2)(H2O)]n (2) [H2L1= (2,3-dihydroxybenzylidene)-2-hydroxybenzohydrazide and H2L2=(2,3-dihydroxybenzylidene)benzohydrazide], have been synthesized and characterized by IR, NMR, elemental analysis and single crystal X-ray diffraction. The antiproliferative potentials of 1 and 2 were examined towards human colorectal carcinoma (HCT116), and lung (A549) and breast (MCF7) adenocarcinoma cell lines. 1 exhibits a high cytotoxic activity against colorectal carcinoma cells (HCT116), with IC50 lower than those for cisplatin.

Entities:  

Keywords:  Antiproliferative agent; Dioxidovanadium(V); Heterometallic complex; X-ray structure

Mesh：

Substances：

Year:  2015        PMID： 26606289     DOI： 10.1016/j.jinorgbio.2015.11.010

Source DB:  PubMed          Journal:  J Inorg Biochem        ISSN： 0162-0134            Impact factor:   4.155


  4 in total

1.  Antitumor activity via apoptotic cell death pathway of water soluble copper(II) complexes: effect of the diamino unit on selectivity against lung cancer NCI-H460 cell line.

Authors:  Wagner da S Terra; Érika S Bull; Samila R Morcelli; Rafaela R Moreira; Leide Laura F Maciel; João Carlos de A Almeida; Milton M Kanashiro; Christiane Fernandes; Adolfo Horn
Journal:  Biometals       Date:  2021-04-04       Impact factor: 2.949

2.  Effect of the hydroxamate group in the antitumoral activity and toxicity toward normal cells of new copper(II) complexes.

Authors:  Nathália F B Azeredo; Franz V Borges; Marcelo S Mathias; Jackson A L C Resende; Roberto W A Franco; Milton M Kanashiro; Adolfo Horn; Christiane Fernandes
Journal:  Biometals       Date:  2021-02-09       Impact factor: 2.949

3.  Gold Nanoparticles for BCR-ABL1 Gene Silencing: Improving Tyrosine Kinase Inhibitor Efficacy in Chronic Myeloid Leukemia.

Authors:  Raquel Vinhas; Alexandra R Fernandes; Pedro V Baptista
Journal:  Mol Ther Nucleic Acids       Date:  2017-05-08

4.  Equilibria in Aqueous Cobalt(II)-Reduced Schiff Base N-(2-hydroxybenzyl)alanine System: Chemical Characterization, Kinetic Analysis, Antimicrobial and Cytotoxic Properties.

Authors:  Magdalena Woźniczka; Manas Sutradhar; Armando J L Pombeiro; Mirosława Świątek; Marek Pająk; Joanna Gądek-Sobczyńska; Magdalena Chmiela; Weronika Gonciarz; Beata Pasternak; Aleksander Kufelnicki
Journal:  Molecules       Date:  2020-07-30       Impact factor: 4.411
  4 in total

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