| Literature DB >> 26606139 |
Naho Morisaki, Mandy B Belfort, Marie C McCormick, Rintaro Mori, Hisashi Noma, Satoshi Kusuda, Masanori Fujimura.
Abstract
Entities:
Year: 2015 PMID: 26606139 PMCID: PMC4659585 DOI: 10.1371/journal.pone.0143984
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Fig 1Population Flow Chart
Fig 2Comparison of nutritional practices in 75 institutions in Japan.
A) Distribution of days to reach 100 ml per kg per day of milk in 8,549 very low birth weight infants (23–32 weeks). B) Variability in usage of parenteral nutrition in very low birth weight infants (23–32 weeks) who reached full enteral feeding within 2 weeks.
Fig 4Estimated effect of administering parenteral nutrition.
A) Change in weight (SD) in situ, B) Change in head circumference (SD) in situ, and C) Length of stay (days). Analysis of 4,005 very low birth weight infants of 24–32 weeks of gestation who reached full enteral feeding within 2 weeks. Legends for Fig 4: Generalized linear mixed models (logistic regression with random intercepts) used to accounting for clustering within institutions. Adjusted for selected maternal (maternal age, number of previous deliveries, number of fetuses, gestational diabetes, pregnancy induced hypertension, use of antenatal steroids, mode of delivery), and infant (gestational length, sex, birth weight, birth head circumference, Apgar score at 5 minutes, days to reach 100 ml per kg per day enteral feeding, length of stay) characteristics. Full enteral feeding: 100 ml per kg per day of milk.
Maternal and infant characteristics of 4,005 very low birth weight infants of 24–32 weeks’ of gestation who reached full enteral feeding within 2 weeks.
| Infants who did not receive parenteral nutrition (n = 2401) | Infants who received parenteral nutrition (n = 1604) | ||
|---|---|---|---|
| Mean (SD) or percentage | |||
| Maternal Characteristics | |||
| Maternal age | 30.6 (5.1) | 31.2 (5.1) | |
| Number of previous deliveries | 0.7 (0.8) | 0.6 (0.8) | |
| Number of fetuses | 1.3 (0.6) | 1.3 (0.6) | |
| Gestational diabetes (%) | 1.6% | 2.1% | |
| Pregnancy induced hypertension (%) | 19.7% | 20.2% | |
| Use of antenatal steroids (%) | 42.9% | 49.1% | |
| Cesarean section (%) | 78.0% | 78.0% | |
| Infant Characteristics | |||
| Gestational length (weeks) | 29.7 (2.0) | 28.7 (2.2) | |
| Length of stay (days) | 75.6 (25.2) | 84.2 (27.0) | |
| Apgar score at 5 minutes | 8.1 (1.4) | 7.7 (1.7) | |
| Days to reach 100ml per kg per day enteral feeding | 8.9 (2.7) | 10.3 (2.5) | |
| Birth Weight (grams) | 1172 (235) | 1049 (258) | |
| Weight for gestational age, at birth (SD) | -0.90 (1.0) | -0.94 (1.2) | |
| Birth Head Circumference (cms) | 26.6(2.0) | 25.7 (2.2) | |
| Weight at discharge (grams) | 2645 (447) | 2707 (495) | |
| Head Circumference at discharge (cms) | 34.2 (1.8) | 34.3 (1.7) | |
| Male (%) | 49.7% | 51.8% | |
| Mechanical ventilation | none (%) | 41.7% | 24.9% |
| Less than 1 week (%) | 35.6% | 32.7% | |
| More than 1 week (%) | 22.7% | 42.4% | |
| Intra-Ventricular Hemorrhage | none (%) | 94.5% | 90.7% |
| Grade 1–2 (%) | 4.1% | 7.4% | |
| Grade 3–4 (%) | 1.0% | 1.9% | |
| Persistent Pulmonary Hypertension of the Newborn(%) | 1.4% | 2.9% | |
| Sepsis(%) | 2.2% | 3.7% | |
| Bronchopulmonary dysplasia (%) | 21.7% | 32.9% | |
| Periventricular Hemorrhage (%) | 2.8% | 3.5% | |
| Extra-uterine growth restriction by weight (%) | 58.1% | 57.9% | |
| Extra-uterine growth restriction by head circumference (%) | 11.5% | 11.5% | |
Full enteral feeding: 100 ml per kg per day of milk.
*: p,0.05.
**: p,0.005.