Literature DB >> 2660363

The new mouse genetics: altering the genome by gene targeting.

M R Capecchi.   

Abstract

Gene targeting (homologous recombination between DNA sequences residing in the chromosome and newly introduced DNA sequences) in pluripotent, mouse embryo-derived stem (ES) cells promises to provide the means to generate mice of any desired genotype. This review describes some of the background and current advances of gene targeting in mouse ES cells.

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Year:  1989        PMID： 2660363     DOI： 10.1016/0168-9525(89)90029-2

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  121 in total

1.  Construction of gene-targeting vectors: a rapid Mu in vitro DNA transposition-based strategy generating null, potentially hypomorphic, and conditional alleles.

Authors:  H Vilen; S Eerikäinen; J Tornberg; M S Airaksinen; H Savilahti
Journal:  Transgenic Res       Date:  2001       Impact factor: 2.788

2.  Consequences of gene targeting procedures for behavioural responses and morphological development of newborn mice.

Authors:  M van der Meer; V Baumans; F M Hofhuis; B Olivier; B F van Zutphen
Journal:  Transgenic Res       Date:  2001-10       Impact factor: 2.788

Review 3.  Gene targeting in the mouse: advances in introduction of transgenes into the genome by homologous recombination.

Authors:  Ravi P Misra; Stephen A Duncan
Journal:  Endocrine       Date:  2002-12       Impact factor: 3.633

4.  A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells.

Authors:  Jean-Charles Epinat; Sylvain Arnould; Patrick Chames; Pascal Rochaix; Dominique Desfontaines; Clémence Puzin; Amélie Patin; Alexandre Zanghellini; Frédéric Pâques; Emmanuel Lacroix
Journal:  Nucleic Acids Res       Date:  2003-06-01       Impact factor: 16.971

5.  A simple and convenient method for preparing chimeric animals from embryonic stem (ES) cells.

Authors:  Pyapalli Usha Rani; Jaspal Singh Khillan
Journal:  Transgenic Res       Date:  2003-12       Impact factor: 2.788

6.  Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus.

Authors:  C Deng; M R Capecchi
Journal:  Mol Cell Biol       Date:  1992-08       Impact factor: 4.272

7.  Targeting of the T-cell receptor zeta-chain gene in embryonic stem cells: strategies for generating multiple mutations in a single gene.

Authors:  P E Love; M L Tremblay; H Westphal
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-15       Impact factor: 11.205

Review 8.  Stem cells and modeling of autism spectrum disorders.

Authors:  Beatriz C G Freitas; Cleber A Trujillo; Cassiano Carromeu; Marianna Yusupova; Roberto H Herai; Alysson R Muotri
Journal:  Exp Neurol       Date:  2012-10-02       Impact factor: 5.330

9.  A Phosphoribosylanthranilate Transferase Gene Is Defective in Blue Fluorescent Arabidopsis thaliana Tryptophan Mutants.

Authors:  A B Rose; A L Casselman; R L Last
Journal:  Plant Physiol       Date:  1992-10       Impact factor: 8.340

10.  Transgenic mice expressing a ligand-inducible cre recombinase in osteoblasts and odontoblasts: a new tool to examine physiology and disease of postnatal bone and tooth.

Authors:  Jung-Eun Kim; Kazuhisa Nakashima; Benoit de Crombrugghe
Journal:  Am J Pathol       Date:  2004-12       Impact factor: 4.307
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