Paul K Crane1, Laura E Gibbons2, Susan M McCurry3, Wayne McCormick2, James D Bowen4, Joshua Sonnen5, C Dirk Keene6, Thomas Grabowski7, Thomas J Montine6, Eric B Larson8. 1. Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address: pcrane@uw.edu. 2. Department of Medicine, University of Washington, Seattle, WA, USA. 3. Department of Psychosocial & Community Health, University of Washington, Seattle, WA, USA. 4. Department of Neurology, Multiple Sclerosis Center, Swedish Neuroscience Institute, Seattle, WA, USA. 5. Department of Pathology, University of Utah, Salt Lake City, UT, USA. 6. Department of Pathology, University of Washington, Seattle, WA, USA. 7. Department of Neurology, University of Washington, Seattle, WA, USA. 8. Group Health Research Institute, Seattle, WA, USA.
Abstract
INTRODUCTION: The importance of home research study visit capacity in Alzheimer's disease (AD) studies is unknown. METHODS: All evaluations are from the prospective Adult Changes in Thought study. Based on analyses of factors associated with volunteering for a new in-clinic initiative, we analyzed AD risk factors and the relevance of neuropathologic findings for dementia comparing all data including home visits, and in-clinic data only. We performed bootstrapping to determine whether differences were greater than expected by chance. RESULTS: Of the 1781 people enrolled during 1994-1996 with ≥1 follow-up, 1369 (77%) had in-clinic data, covering 61% of follow-up time. In-clinic data resulted in excluding 76% of incident dementia and AD cases. AD risk factors and the relevance of neuropathologic findings for dementia were both different with in-clinic data. DISCUSSION: Limiting data collection in AD studies to research clinics alone likely reduces power and also can lead to erroneous inferences.
INTRODUCTION: The importance of home research study visit capacity in Alzheimer's disease (AD) studies is unknown. METHODS: All evaluations are from the prospective Adult Changes in Thought study. Based on analyses of factors associated with volunteering for a new in-clinic initiative, we analyzed AD risk factors and the relevance of neuropathologic findings for dementia comparing all data including home visits, and in-clinic data only. We performed bootstrapping to determine whether differences were greater than expected by chance. RESULTS: Of the 1781 people enrolled during 1994-1996 with ≥1 follow-up, 1369 (77%) had in-clinic data, covering 61% of follow-up time. In-clinic data resulted in excluding 76% of incident dementia and AD cases. AD risk factors and the relevance of neuropathologic findings for dementia were both different with in-clinic data. DISCUSSION: Limiting data collection in AD studies to research clinics alone likely reduces power and also can lead to erroneous inferences.
Keywords:
Bias; Cohort studies; Dementia; Home research study visits; Inference; Longitudinal studies; Missing data; Neuropathology; Prospective studies; Research clinic study visits
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