Nursen Keles1, Burcu Dogan2, Macit Kalcik3, Mustafa Caliskan4, Necibe Nur Keles5, Feyza Aksu4, Mustafa Bulut6, Osman Kostek7, Banu Isbilen8, Yusuf Yilmaz4, Aytekin Oguz7. 1. Istanbul Medeniyet University, Goztepe Training and Research Hospital, Department of Cardiology, İstanbul, Turkey. Electronic address: drnursenkeles@yahoo.com.tr. 2. Istanbul Medeniyet University, Goztepe Training and Research Hospital, Department of Family Physicians, Istanbul, Turkey. 3. Iskilip Atif Hoca State Hospital, Department of Cardiology, Corum, Turkey. 4. Istanbul Medeniyet University, Goztepe Training and Research Hospital, Department of Cardiology, İstanbul, Turkey. 5. Eyup Government Hospital Neurology Clinics, Istanbul, Turkey. 6. İstanbul Kartal Kosuyolu Yuksek Ihtisas Training and Research Hospital, Istanbul, Turkey. 7. Istanbul Medeniyet University, Goztepe Training and Research Hospital, Department of Internal Medicine, Istanbul, Turkey. 8. Istanbul Medeniyet University, Goztepe Training and Research Hospital, Department of Biochemistry, Istanbul, Turkey.
Abstract
OBJECTIVE: Klotho deficiency is associated with several metabolic disorders. Two dimensional (2D) longitudinal strain (LS) of left ventricle (LV), carotid artery intima-media thickness (CIMT), flow-mediated dilation (FMD) of brachial artery and epicardial fat thickness (EFT) have been reported to be early predictors of atherosclerosis. We aimed to investigate the relationship between serum Klotho levels and these early predictors of atherosclerosis in patients with type 1 diabetes mellitus (DM). METHODS: The study included 45 type 1 diabetic patients and 35 controls. Serum Klotho levels were determined by ELISA method. The patient group was also divided into two subgroups according to serum Klotho levels: high (HK) and low Klotho (LK) groups. EFT, CIMT and FMD were measured according to appropriate recommendations. Speckle tracking analysis was performed using the Echopac software. RESULTS: The patient group had significantly lower serum Klotho (p=0.001), FMD (p<0.001) and LS of LV (p<0.001) values, but larger EFT (p<0.001) and CIMT (p<0.001) values than controls. LK subgroup had also significantly lower FMD (p<0.001) and LS of LV (p<0.001) but larger EFT (p=0.002) and CIMT (p<0.001) values than HK subgroup. CONCLUSION: Serum Klotho may have a protective effect against atherosclerosis and endothelial dysfunction in type 1 DM.
OBJECTIVE:Klotho deficiency is associated with several metabolic disorders. Two dimensional (2D) longitudinal strain (LS) of left ventricle (LV), carotid artery intima-media thickness (CIMT), flow-mediated dilation (FMD) of brachial artery and epicardial fat thickness (EFT) have been reported to be early predictors of atherosclerosis. We aimed to investigate the relationship between serum Klotho levels and these early predictors of atherosclerosis in patients with type 1 diabetes mellitus (DM). METHODS: The study included 45 type 1 diabeticpatients and 35 controls. Serum Klotho levels were determined by ELISA method. The patient group was also divided into two subgroups according to serum Klotho levels: high (HK) and low Klotho (LK) groups. EFT, CIMT and FMD were measured according to appropriate recommendations. Speckle tracking analysis was performed using the Echopac software. RESULTS: The patient group had significantly lower serum Klotho (p=0.001), FMD (p<0.001) and LS of LV (p<0.001) values, but larger EFT (p<0.001) and CIMT (p<0.001) values than controls. LK subgroup had also significantly lower FMD (p<0.001) and LS of LV (p<0.001) but larger EFT (p=0.002) and CIMT (p<0.001) values than HK subgroup. CONCLUSION: Serum Klotho may have a protective effect against atherosclerosis and endothelial dysfunction in type 1 DM.