Literature DB >> 26597910

Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard.

H Cheloufi1, B Belhani1, T S Ouk2, R Zerrouki2, N-E Aouf1, M Berredjem3.   

Abstract

A new series of sulfonylcycloureas derivatives have been synthesized and evaluated in vitro for their antitumor activity against four cancer cell lines (A431, Jurkat, U266, and K562). These compounds were prepared by the condensation of several sulfonamides (2a-m) with ethyl bis(2-chloroethyl)carbamate (1a). The relative cytotoxicity of these new derivatives in comparison to chlorambucil is reported.

Entities:  

Keywords:  Antitumor; Cancer; Nitrogen mustard; Sulfonamides; Sulfonylcycloureas

Mesh：

Substances：

Year:  2015        PMID： 26597910     DOI： 10.1007/s11030-015-9647-6

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  28 in total

1.  Carbonic anhydrases inhibitory effects of new benzenesulfonamides synthesized by using superacid chemistry.

Authors:  Fei Liu; Agnès Martin-Mingot; F Lecornué; Marie-Paule Jouannetaud; Alfonso Maresca; Sebastien Thibaudeau; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2011-12-14       Impact factor: 5.051

2.  Synthesis and in vitro antitumor evaluation of some indeno[1,2-c]pyrazol(in)es substituted with sulfonamide, sulfonylurea(-thiourea) pharmacophores, and some derived thiazole ring systems.

Authors:  Sherif A F Rostom
Journal:  Bioorg Med Chem       Date:  2006-06-27       Impact factor: 3.641

3.  Design, synthesis and cytotoxic activity of novel sulfonylurea derivatives of podophyllotoxin.

Authors:  Zhi-Jun Zhang; Jing Tian; Li-Ting Wang; Mei-Juan Wang; Xiang Nan; Liu Yang; Ying-Qian Liu; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem       Date:  2013-11-28       Impact factor: 3.641

4.  Novel agents effective against solid tumors: the diarylsulfonylureas. Synthesis, activities, and analysis of quantitative structure-activity relationships.

Authors:  J J Howbert; C S Grossman; T A Crowell; B J Rieder; R W Harper; K E Kramer; E V Tao; J Aikins; G A Poore; S M Rinzel
Journal:  J Med Chem       Date:  1990-09       Impact factor: 7.446

5.  Synthesis and antitumor evaluation of novel cyclic arylsulfonylureas: ADME-T and pharmacophore prediction.

Authors:  Ibrahim M El-Deeb; Said M Bayoumi; Magda A El-Sherbeny; Alaa A-M Abdel-Aziz
Journal:  Eur J Med Chem       Date:  2010-02-20       Impact factor: 6.514

6.  Pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors with antitumor activity.

Authors:  Mariusz Mojzych; Anna Bielawska; Krzysztof Bielawski; Mariangela Ceruso; Claudiu T Supuran
Journal:  Bioorg Med Chem       Date:  2014-03-27       Impact factor: 3.641

7.  In vitro antitumor activity of N-glycosyl sulfonamides.

Authors:  Rosana Crespo; Margarita G de Bravo; Pedro A Colinas; Rodolfo D Bravo
Journal:  Bioorg Med Chem Lett       Date:  2010-09-16       Impact factor: 2.823

8.  Design, synthesis, and biological evaluation of novel water-soluble N-mustards as potential anticancer agents.

Authors:  Naval Kapuriya; Rajesh Kakadiya; Huajin Dong; Amit Kumar; Pei-Chih Lee; Xiuguo Zhang; Ting-Chao Chou; Te-Chang Lee; Ching-Huang Chen; King Lam; Bhavin Marvania; Anamik Shah; Tsann-Long Su
Journal:  Bioorg Med Chem       Date:  2010-11-05       Impact factor: 3.641

9.  Synthesis and evaluation of sulfonylurea derivatives as novel antimalarials.

Authors:  Caritza León; Juan Rodrigues; Neira Gamboa de Domínguez; Jaime Charris; Jiri Gut; Philip J Rosenthal; José N Domínguez
Journal:  Eur J Med Chem       Date:  2007-01-14       Impact factor: 6.514

10.  Bicyclic core estrogens as full antagonists: synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides.

Authors:  Manghong Zhu; Chen Zhang; Jerome C Nwachukwu; Sathish Srinivasan; Valerie Cavett; Yangfan Zheng; Kathryn E Carlson; Chune Dong; John A Katzenellenbogen; Kendall W Nettles; Hai-Bing Zhou
Journal:  Org Biomol Chem       Date:  2012-11-21       Impact factor: 3.876
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