Literature DB >> 22168802

Carbonic anhydrases inhibitory effects of new benzenesulfonamides synthesized by using superacid chemistry.

Fei Liu1, Agnès Martin-Mingot, F Lecornué, Marie-Paule Jouannetaud, Alfonso Maresca, Sebastien Thibaudeau, Claudiu T Supuran.   

Abstract

A series of benzofused sultams and fluorinated benzenesulfonamides were synthesized in superacid HF/SbF(5) from simple N-allylic derivatives. Almost all of these original compounds showed micromolar inhibitory activities against carbonic anhydrases I and II. The fluorinated derivatives inhibit better the tumor-associated isoforms IX and XII, and one of the tested compounds showed inhibition in the nanomolar range.

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Year:  2011        PMID： 22168802     DOI： 10.3109/14756366.2011.638921

Source DB:  PubMed          Journal:  J Enzyme Inhib Med Chem        ISSN： 1475-6366            Impact factor:   5.051


  2 in total

1.  Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard.

Authors:  H Cheloufi; B Belhani; T S Ouk; R Zerrouki; N-E Aouf; M Berredjem
Journal:  Mol Divers       Date:  2015-11-23       Impact factor: 2.943

2.  Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms.

Authors:  Melissa D'Ascenzio; Paolo Guglielmi; Simone Carradori; Daniela Secci; Rosalba Florio; Adriano Mollica; Mariangela Ceruso; Atilla Akdemir; Anatoly P Sobolev; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2016-10-26       Impact factor: 5.051
  2 in total

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