Patrick Goeres1, Frederick A Zeiler2, Bertram Unger3, Dimitrios Karakitsos4, Lawrence M Gillman5. 1. Department of Surgery, University of Manitoba, Winnipeg, MB, Canada. Electronic address: goeresp@myumanitoba.ca. 2. Department of Surgery, University of Manitoba, Winnipeg, MB, Canada. Electronic address: umzeiler@cc.umanitoba.ca. 3. Department of Medical Education, University of Manitoba, Winnipeg, MB, Canada. Electronic address: bertram.j.unger@gmail.com. 4. Department of Internal Medicine, University of South Carolina, Columbia, SC. Electronic address: karakitsosdimitrios@gmail.com. 5. Department of Surgery, University of Manitoba, Winnipeg, MB, Canada. Electronic address: gillmanlm@yahoo.ca.
Abstract
BACKGROUND: Ultrasound assessment of optic nerve sheath diameter (ONSD) has been suggested as a non-invasive measure of intracranial pressure. Numerous small studies suggest its validity; however, discrepancy exists around normal values for ONSD. In this study we sought to define a normal value range for ONSD in a population of healthy adult volunteers. METHODS: ONSD was measured in healthy adult volunteers and a normal range was defined using descriptive statistics. A regression analysis was used to determine relationship between ONSD measurements and sex, age, height and weight. RESULTS: One hundred twenty adults were recruited (age 18-65 [mean 29.3]) with 55 male and 65 female subjects. Mean ONSD was 3.68 mm (95% confidence interval [CI], 2.85-4.40). Upon regression analysis, mean ONSD did not vary with age, weight, or height but did vary with sex. Mean ONSD measurements for men were 3.78 mm (95% CI, 3.23-4.48) compared with 3.60 mm (95% CI, 2.83-4.11) for women. CONCLUSION: This study has defined the range of ONSD in a healthy cohort of volunteers. The lack of relationship to age, weight and height is similar to other studies but this is the first study to find a difference depending on sex suggesting the possible need for separate reference ranges for men and women.
BACKGROUND: Ultrasound assessment of optic nerve sheath diameter (ONSD) has been suggested as a non-invasive measure of intracranial pressure. Numerous small studies suggest its validity; however, discrepancy exists around normal values for ONSD. In this study we sought to define a normal value range for ONSD in a population of healthy adult volunteers. METHODS: ONSD was measured in healthy adult volunteers and a normal range was defined using descriptive statistics. A regression analysis was used to determine relationship between ONSD measurements and sex, age, height and weight. RESULTS: One hundred twenty adults were recruited (age 18-65 [mean 29.3]) with 55 male and 65 female subjects. Mean ONSD was 3.68 mm (95% confidence interval [CI], 2.85-4.40). Upon regression analysis, mean ONSD did not vary with age, weight, or height but did vary with sex. Mean ONSD measurements for men were 3.78 mm (95% CI, 3.23-4.48) compared with 3.60 mm (95% CI, 2.83-4.11) for women. CONCLUSION: This study has defined the range of ONSD in a healthy cohort of volunteers. The lack of relationship to age, weight and height is similar to other studies but this is the first study to find a difference depending on sex suggesting the possible need for separate reference ranges for men and women.
Authors: C E Al-Haddad; M G Sebaaly; R N Tutunji; C J Mehanna; S R Saaybi; A M Khamis; R G Hourani Journal: AJNR Am J Neuroradiol Date: 2017-12-07 Impact factor: 3.825
Authors: Garrett G R J Johnson; Frederick A Zeiler; Bertram Unger; Gregory Hansen; Dimitrios Karakitsos; Lawrence M Gillman Journal: Crit Ultrasound J Date: 2016-11-10
Authors: Ibrahim Soliman; Garrett G R J Johnson; Lawrence M Gillman; Frederick A Zeiler; Fahad Faqihi; Waleed Tharwat Aletreby; Abdullah Balhamar; Nasir Nasim Mahmood; Shahzad Ahmad Mumtaz; Abdulrahman Alharthy; Christos Lazaridis; Dimitrios Karakitsos Journal: Crit Care Res Pract Date: 2018-04-30
Authors: Frederick A Zeiler; Markus T Ziesmann; Patrick Goeres; Bertram Unger; Jason Park; Dimitrios Karakitsos; Michael Blaivas; Ashley Vergis; Lawrence M Gillman Journal: Crit Ultrasound J Date: 2016-08-08
Authors: Jin Pyeong Jeon; Si Un Lee; Sung-Eun Kim; Suk Hyung Kang; Jin Seo Yang; Hyuk Jai Choi; Yong Jun Cho; Seung Pil Ban; Hyoung Soo Byoun; Young Soo Kim Journal: PLoS One Date: 2017-09-13 Impact factor: 3.240