Literature DB >> 26594904

Cytotoxic activity and molecular docking of a novel biflavonoid isolated from Jacaranda acutifolia (Bignoniaceae).

Nada M Mostafa1, Mohamed L Ashour1, Omayma A Eldahshan1, Abdel Nasser B Singab1.   

Abstract

A novel biflavonoid [kaempferol (6→8″) apigenin] was isolated from the leaves of Jacaranda acutifolia. The structure was elucidated based on chemical evidence, 1D and 2D spectroscopic analyses as well as spectrometric techniques. The compound showed promising cytotoxic activity against breast cancer cell line MCF-7. The anticancer activity was explained via virtual docking of the isolated compound to the main sites in the human cyclin-dependent kinase2 (CDK2) crystal structure.

Entities:  

Keywords:  Bignoniaceae; Jacaranda acutifolia; biflavonoid; cytotoxic activity; molecular docking

Mesh：

Substances：

Year:  2015        PMID： 26594904     DOI： 10.1080/14786419.2015.1114938

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN： 1478-6419            Impact factor:   2.861


  7 in total

1.  GC/MS analysis and potential synergistic effect of mandarin and marjoram oils on Helicobacter pylori.

Authors:  Rawah H Elkousy; Nada M Mostafa; Ahmed M Abd-Alkhalek; Mahmoud A El Hassab; Sara T Al-Rashood; Wagdy M Eldehna; Omayma A Eldahshan
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.756

2.  GC/MS Profiling, Anti-Collagenase, Anti-Elastase, Anti-Tyrosinase and Anti-Hyaluronidase Activities of a Stenocarpus sinuatus Leaves Extract.

Authors:  Mai M Younis; Iriny M Ayoub; Nada M Mostafa; Mahmoud A El Hassab; Wagdy M Eldehna; Sara T Al-Rashood; Omayma A Eldahshan
Journal:  Plants (Basel)       Date:  2022-03-29

3.  Inhibition of Cytochrome P450 (CYP3A4) Activity by Extracts from 57 Plants Used in Traditional Chinese Medicine (TCM).

Authors:  Mohamed L Ashour; Fadia S Youssef; Haidy A Gad; Michael Wink
Journal:  Pharmacogn Mag       Date:  2017-04-18       Impact factor: 1.085

4.  UPLC-PDA-MS/MS Profiling and Healing Activity of Polyphenol-Rich Fraction of Alhagi maurorum against Oral Ulcer in Rats.

Authors:  Hala El-Zahar; Esther T Menze; Heba Handoussa; Ahmed K Osman; Mohamed El-Shazly; Nada M Mostafa; Noha Swilam
Journal:  Plants (Basel)       Date:  2022-02-07

5.  Effect of Ling-Gui-Zhu-Gan decoction major components on the plasma protein binding of metoprolol using UPLC analysis coupled with ultrafiltration.

Authors:  Peng Zhou; Jinling Huang; Wanxue Ding
Journal:  RSC Adv       Date:  2018-10-22       Impact factor: 4.036

6.  GC-MS metabolites profiling of anethole-rich oils by different extraction techniques: antioxidant, cytotoxicity and in-silico enzymes inhibitory insights.

Authors:  Dina M El-Kersh; Nada M Mostafa; Shaimaa Fayez; Tarfah Al-Warhi; Mohammed A S Abourehab; Wagdy M Eldehna; Mohamed A Salem
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.756

Review 7.  Herbal Arsenal against Skin Ailments: A Review Supported by In Silico Molecular Docking Studies.

Authors:  Abdel Nasser B Singab; Nada M Mostafa; Iten M Fawzy; Deepika Bhatia; Pooja Tanaji Suryawanshi; Atul Kabra
Journal:  Molecules       Date:  2022-09-21       Impact factor: 4.927
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.