Literature DB >> 26594765

α-Glucosidase and 15-Lipoxygenase Inhibitory Activities of Phytochemicals from Calophyllum symingtonianum.

Nurul Iman Aminudin, Farediah Ahmad, Muhammad Taher, Razauden Mohamed Zulkifli.   

Abstract

A phytochemical investigation of the crude extracts of the bark and leaves of Calophyllum symingtonianum has resulted in the isolation of inophyllum D, inophyllum H, calanone, isocordato-oblongic acid, amentoflavone, carpachromene and lupenone. Their chemical structures were elucidated and confirmed by spectroscopic analysis. All flavonoids and coumarins showed significant α-glucosidase inhibitory activity, while amentoflavone gave a positive result against 15-lipoxygenase inhibition.

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Year:  2015        PMID： 26594765

Source DB:  PubMed          Journal:  Nat Prod Commun        ISSN： 1555-9475            Impact factor:   0.986


  5 in total

Review 1.  A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid.

Authors:  Sheng Yu; Hui Yan; Li Zhang; Mingqiu Shan; Peidong Chen; Anwei Ding; Sam Fong Yau Li
Journal:  Molecules       Date:  2017-02-16       Impact factor: 4.411

2.  In Vitro Evaluation and Docking Studies of 5-oxo-5H-furo[3,2-g]chromene-6-carbaldehyde Derivatives as Potential Anti-Alzheimer's Agents.

Authors:  Malose J Mphahlele; Samantha Gildenhuys; Emmanuel N Agbo
Journal:  Int J Mol Sci       Date:  2019-11-01       Impact factor: 5.923

3.  Exploring Biological Activity of 4-Oxo-4H-furo[2,3-h]chromene Derivatives as Potential Multi-Target-Directed Ligands Inhibiting Cholinesterases, β-Secretase, Cyclooxygenase-2, and Lipoxygenase-5/15.

Authors:  Malose J Mphahlele; Emmanuel N Agbo; Samantha Gildenhuys; Itumeleng B Setshedi
Journal:  Biomolecules       Date:  2019-11-13

4.  Improving the Antioxidant Properties of Calophyllum inophyllum Seed Oil from French Polynesia: Development and Biological Applications of Resinous Ethanol-Soluble Extracts.

Authors:  Mathieu Cassien; Anne Mercier; Sophie Thétiot-Laurent; Marcel Culcasi; Emilie Ricquebourg; Alice Asteian; Gaëtan Herbette; Jean-Pierre Bianchini; Phila Raharivelomanana; Sylvia Pietri
Journal:  Antioxidants (Basel)       Date:  2021-01-30

5.  Carpachromene Ameliorates Insulin Resistance in HepG2 Cells via Modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 Pathway.

Authors:  Rania Alaaeldin; Iman A M Abdel-Rahman; Heba Ali Hassan; Nancy Youssef; Ahmed E Allam; Sayed F Abdelwahab; Qing-Li Zhao; Moustafa Fathy
Journal:  Molecules       Date:  2021-12-16       Impact factor: 4.411
  5 in total

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