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Literature DB >> 26590711

Cancer's Fuel Choice: New Flavors for a Picky Eater.

Abstract

Otto Warburg discovered that cancer cells exhibit a high rate of glycolysis in the presence of ample oxygen, a process termed aerobic glycolysis, in 1924 (Warburg et al., 1924). Since then we have significantly advanced our understanding of cancers' fuel choice to meet their demands for energy and for the production of biosynthetic precursors. In this review, we will discuss the preferred nutrients of cancer cells and how they are utilized to satisfy their bioenergetic and biosynthetic needs. In addition, we will describe how cell intrinsic and extrinsic factors such as oncogene mutations, nutrient and oxygen availability, and other microenvironmental factors influence fuel choice.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Substances：
Oxygen

Year: 2015 PMID： 26590711 PMCID： PMC4676726 DOI： 10.1016/j.molcel.2015.10.018

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

68 in total

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57 in total

Review 1. Pyruvate and Metabolic Flexibility: Illuminating a Path Toward Selective Cancer Therapies.

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Journal: J Clin Invest Date: 2020-06-01 Impact factor: 14.808

Review 3. Lymphangioleiomyomatosis: A Monogenic Model of Malignancy.

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Journal: Cell Res Date: 2016-09-20 Impact factor: 25.617

5. Differential contribution of the mitochondrial translation pathway to the survival of diffuse large B-cell lymphoma subsets.

Authors: Erik Norberg; Ana Lako; Pei-Hsuan Chen; Illana A Stanley; Feng Zhou; Scott B Ficarro; Bjoern Chapuy; Linfeng Chen; Scott Rodig; Donghyuk Shin; Dong Wook Choi; Sangho Lee; Margaret A Shipp; Jarrod A Marto; Nika N Danial
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Journal: Cell Metab Date: 2019-12-05 Impact factor: 27.287