Seong Bin Hong1, Jung Jin Lee2, So Hun Kim1, Young Ju Suh3, Ju Young Han1, Yong Seong Kim1, Moonsuk Nam4. 1. Department of Endocrinology, Inha University School of Medicine, Incheon, Republic of Korea. 2. Department of Endocrinology, Inha University School of Medicine, Incheon, Republic of Korea; Department of Internal Medicine, Hallym General Hospital, Incheon, Republic of Korea. 3. Department of Biomedical Sciences, Inha University School of Medicine, Incheon, Republic of Korea. 4. Department of Endocrinology, Inha University School of Medicine, Incheon, Republic of Korea. Electronic address: namms@inha.ac.kr.
Abstract
AIMS: To evaluate the associations between inflammatory cytokines and adiponectin and various vascular complications in type 2 diabetes mellitus (T2DM). METHODS: A total of 761 patients with T2DM were divided into a non-obese group and an obese group to enable the effects of obesity and T2DM on vascular complications to be differentiated. The serum levels of circulating inflammatory cytokines, that is, tumor necrosis factor (TNF)-α, and interleukin (IL)-6, total adiponectin, and high molecular weight (HMW) adiponectin were measured, and carotid intima media thickness (IMT), the presence of carotid plaque, and the severities of retinopathy and nephropathy, were assessed. RESULTS: The obese group had significantly lower serum total and HMW adiponectin levels than the non-obese group. In the obese group, serum levels of total and HMW adiponectin, and TNF-α were significantly higher in patients with proliferative retinopathy than in those without retinopathy after adjusting for covariates. In the non-obese group, only IL-6 levels were significantly higher in patients with proliferative retinopathy than in those without. Serum levels of total and HMW adiponectin were significantly higher in patients with macroalbuminuria than in those with normoalbuminuria. No significant difference of three cytokines levels were observed depending on the carotid IMT or the presence of plaque. Logistic regression analysis revealed that serum total adiponectin (OR=1.209, P=0.038), diabetes duration (OR=1.230, P=0.014), and HbA1c (OR=2.359, P=0.006) were significantly associated with proliferative retinopathy in the obese group. CONCLUSION: The study shows total adiponectin may influence proliferative retinopathy in obese patient with T2DM.
AIMS: To evaluate the associations between inflammatory cytokines and adiponectin and various vascular complications in type 2 diabetes mellitus (T2DM). METHODS: A total of 761 patients with T2DM were divided into a non-obese group and an obese group to enable the effects of obesity and T2DM on vascular complications to be differentiated. The serum levels of circulating inflammatory cytokines, that is, tumor necrosis factor (TNF)-α, and interleukin (IL)-6, total adiponectin, and high molecular weight (HMW) adiponectin were measured, and carotid intima media thickness (IMT), the presence of carotid plaque, and the severities of retinopathy and nephropathy, were assessed. RESULTS: The obese group had significantly lower serum total and HMW adiponectin levels than the non-obese group. In the obese group, serum levels of total and HMW adiponectin, and TNF-α were significantly higher in patients with proliferative retinopathy than in those without retinopathy after adjusting for covariates. In the non-obese group, only IL-6 levels were significantly higher in patients with proliferative retinopathy than in those without. Serum levels of total and HMW adiponectin were significantly higher in patients with macroalbuminuria than in those with normoalbuminuria. No significant difference of three cytokines levels were observed depending on the carotid IMT or the presence of plaque. Logistic regression analysis revealed that serum total adiponectin (OR=1.209, P=0.038), diabetes duration (OR=1.230, P=0.014), and HbA1c (OR=2.359, P=0.006) were significantly associated with proliferative retinopathy in the obese group. CONCLUSION: The study shows total adiponectin may influence proliferative retinopathy in obesepatient with T2DM.
Authors: Da Hea Seo; So Hun Kim; Joon Ho Song; Seongbin Hong; Young Ju Suh; Seong Hee Ahn; Jeong Taek Woo; Sei Hyun Baik; Yongsoo Park; Kwan Woo Lee; Young Seol Kim; Moonsuk Nam Journal: Diabetes Metab J Date: 2019-03-12 Impact factor: 5.376
Authors: Mostafa Wanees Ahmed El Husseny; Mediana Mamdouh; Sara Shaban; Abdelrahman Ibrahim Abushouk; Marwa Mostafa Mohamed Zaki; Osama M Ahmed; Mohamed M Abdel-Daim Journal: J Diabetes Res Date: 2017-02-13 Impact factor: 4.011