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Literature DB >> 2658742

Molecular pathogenesis of Ph-positive leukemias.

Abstract

The strong association between the Philadelphia chromosome (Ph) and chronic myelogenous leukemia (CML) suggests that the Ph translocation plays a significant role in CML pathogenesis. For this reason, Ph-positive leukemias have been well studied from the molecular, clinical, and cell biological perspective. We attempt to integrate these data in order to better our understanding of the role of the Ph chromosome in human leukemia.

Entities: Disease Species

Mesh：

Year: 1989 PMID： 2658742 DOI： 10.1146/annurev.me.40.020189.000553

Source DB: PubMed Journal: Annu Rev Med ISSN： 0066-4219 Impact factor: 13.739

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Cited

8 in total

Review 1. Natural variation in Arabidopsis: from molecular genetics to ecological genomics.

Authors: Detlef Weigel
Journal: Plant Physiol Date: 2011-12-06 Impact factor: 8.340

2. The 5' noncoding region of the human leukemia-associated oncogene BCR/ABL is a potent inhibitor of in vitro translation.

Authors: A J Muller; O N Witte
Journal: Mol Cell Biol Date: 1989-11 Impact factor: 4.272

3. Structural alterations of the BCR and ABL genes in Ph1 positive acute leukemias with rearrangements in the BCR gene first intron: further evidence implicating Alu sequences in the chromosome translocation.

Authors: S J Chen; Z Chen; M P Font; L d'Auriol; C J Larsen; R Berger
Journal: Nucleic Acids Res Date: 1989-10-11 Impact factor: 16.971

4. BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

Authors: A J Muller; J C Young; A M Pendergast; M Pondel; N R Landau; D R Littman; O N Witte
Journal: Mol Cell Biol Date: 1991-04 Impact factor: 4.272

5. A 41-kilodalton protein is a potential substrate for the p210bcr-abl protein-tyrosine kinase in chronic myelogenous leukemia cells.

Authors: E Freed; T Hunter
Journal: Mol Cell Biol Date: 1992-03 Impact factor: 4.272

Molecular pathogenesis of Ph-positive leukemias.

Review 1. Natural variation in Arabidopsis: from molecular genetics to ecological genomics.

2. The 5' noncoding region of the human leukemia-associated oncogene BCR/ABL is a potent inhibitor of in vitro translation.

3. Structural alterations of the BCR and ABL genes in Ph1 positive acute leukemias with rearrangements in the BCR gene first intron: further evidence implicating Alu sequences in the chromosome translocation.

4. BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias.

5. A 41-kilodalton protein is a potential substrate for the p210bcr-abl protein-tyrosine kinase in chronic myelogenous leukemia cells.

6. BCR-ABL and v-abl oncogenes induce distinct patterns of thymic lymphoma involving different lymphocyte subsets.

7. Differences in oncogenic potency but not target cell specificity distinguish the two forms of the BCR/ABL oncogene.

8. Functional analysis of the AUG- and CUG-initiated forms of the c-Myc protein.