Literature DB >> 26586516

A protocol for amide bond formation with electron deficient amines and sterically hindered substrates.

Maria E Due-Hansen1, Sunil K Pandey, Elisabeth Christiansen, Rikke Andersen, Steffen V F Hansen, Trond Ulven.   

Abstract

A protocol for amide coupling by in situ formation of acyl fluorides and reaction with amines at elevated temperature has been developed and found to be efficient for coupling of sterically hindered substrates and electron deficient amines where standard methods failed.

Entities:  

Year:  2016        PMID： 26586516     DOI： 10.1039/c5ob02129d

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  8 in total

1.  The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue Recruitment.

Authors:  Lena Björkman; Jonas Mårtensson; Malene Winther; Michael Gabl; André Holdfeldt; Martin Uhrbom; Johan Bylund; Anders Højgaard Hansen; Sunil K Pandey; Trond Ulven; Huamei Forsman; Claes Dahlgren
Journal:  Mol Cell Biol       Date:  2016-09-26       Impact factor: 4.272

2.  Synthesis of amide derivatives for electron deficient amines and functionalized carboxylic acids using EDC and DMAP and a catalytic amount of HOBt as the coupling reagents.

Authors:  Arun K Ghosh; Dana Shahabi
Journal:  Tetrahedron Lett       Date:  2020-12-25       Impact factor: 2.415

3.  Optimization of a Pyrimidinone Series for Selective Inhibition of Ca2+/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain.

Authors:  Jason A Scott; Monica Soto-Velasquez; Michael P Hayes; Justin E LaVigne; Heath R Miller; Jatinder Kaur; Karin F K Ejendal; Val J Watts; Daniel P Flaherty
Journal:  J Med Chem       Date:  2022-03-10       Impact factor: 8.039

4.  Optimization of Automated Synthesis of Amide-Linked RNA.

Authors:  Julien A Viel; Chandan Pal; Eriks Rozners
Journal:  ACS Omega       Date:  2022-05-31

5.  Synthesis and Structural Properties of Adamantane-Substituted Amines and Amides Containing an Additional Adamantane, Azaadamantane or Diamantane Moiety.

Authors:  Maxime Bonsir; Alan R Kennedy; Yves Geerts
Journal:  ChemistryOpen       Date:  2022-03-04       Impact factor: 2.630

6.  A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional Bias.

Authors:  Daniele Bolognini; Catherine E Moss; Karolina Nilsson; Annika U Petersson; Iona Donnelly; Eugenia Sergeev; Gabriele M König; Evi Kostenis; Mariola Kurowska-Stolarska; Ashley Miller; Niek Dekker; Andrew B Tobin; Graeme Milligan
Journal:  J Biol Chem       Date:  2016-07-05       Impact factor: 5.157

7.  Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91.

Authors:  Mette Trauelsen; Elisabeth Rexen Ulven; Siv A Hjorth; Matjaz Brvar; Claudia Monaco; Thomas M Frimurer; Thue W Schwartz
Journal:  Mol Metab       Date:  2017-09-30       Impact factor: 7.422

8.  Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1.

Authors:  Elisabeth Rexen Ulven; Mette Trauelsen; Matjaz Brvar; Michael Lückmann; Line Ø Bielefeldt; Lisa K I Jensen; Thue W Schwartz; Thomas M Frimurer
Journal:  Sci Rep       Date:  2018-07-03       Impact factor: 4.379
  8 in total

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