Barbara Medoff-Cooper1, Sharon Y Irving2, Alexandra L Hanlon3, Nadya Golfenshtein3, Jerilynn Radcliffe4, Virginia A Stallings5, Bradley S Marino6, Chitra Ravishankar7. 1. University of Pennsylvania School of Nursing, Philadelphia, PA; The Children's Hospital of Philadelphia, Philadelphia, PA. Electronic address: medoff@nursing.upenn.edu. 2. University of Pennsylvania School of Nursing, Philadelphia, PA; The Children's Hospital of Philadelphia, Philadelphia, PA. 3. University of Pennsylvania School of Nursing, Philadelphia, PA. 4. The Children's Hospital of Philadelphia, Philadelphia, PA. 5. University of Pennsylvania Perelman School of Medicine; Department of Gastroenterology, The Children's Hospital of Philadelphia, Philadelphia, PA. 6. Northwestern University Feinberg School of Medicine; Department of Cardiology, Anne and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL. 7. Department of Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Abstract
OBJECTIVE: To assess the association between early anthropometric measurements, device-assisted feeding, and early neurodevelopment in infants with complex congenital heart diseases (CHDs). STUDY DESIGN: Bayley Scales of Infant Development II were used to assess cognitive and motor skills in 72 infants with CHD at 6 and 12 months of age. Linear regression models were used to assess the association between mode of feeding and anthropometric measurements with neurodevelopment at 6 and 12 months of age. RESULTS: Of the 72 infants enrolled in the study, 34 (47%) had single-ventricle physiology. The mean Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI) scores at 6 months of age were 92 ± 10 and 81 ± 14, respectively. At 12 months of age, the mean MDI and PDI scores were 94 ± 12 and 80 ± 16, respectively. Lower length-for-age z score (P < .01) and head circumference-for-age z score (P < .05) were independently associated with lower MDI at 6 months, and both increased hospital length of stay (P < .01) and lower length-for-age z score (P = .04) were associated independently with lower MDI at 12 months. Device-assisted feeding at 3 months (P = .04) and lower length-for-age z score (P < .05) were independently associated with lower PDI at 6 months. Both lower weight-for-age z score (P = .04) and lower length-for-age z score (P = .04) were associated independently with PDI at 12 months. CONCLUSION: Neonates with complex CHD who required device-assisted feeding and those with lower weight and length and head circumference z scores at 3 months were at risk for neurodevelopmental delay at 6 and 12 months of age.
OBJECTIVE: To assess the association between early anthropometric measurements, device-assisted feeding, and early neurodevelopment in infants with complex congenital heart diseases (CHDs). STUDY DESIGN: Bayley Scales of Infant Development II were used to assess cognitive and motor skills in 72 infants with CHD at 6 and 12 months of age. Linear regression models were used to assess the association between mode of feeding and anthropometric measurements with neurodevelopment at 6 and 12 months of age. RESULTS: Of the 72 infants enrolled in the study, 34 (47%) had single-ventricle physiology. The mean Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI) scores at 6 months of age were 92 ± 10 and 81 ± 14, respectively. At 12 months of age, the mean MDI and PDI scores were 94 ± 12 and 80 ± 16, respectively. Lower length-for-age z score (P < .01) and head circumference-for-age z score (P < .05) were independently associated with lower MDI at 6 months, and both increased hospital length of stay (P < .01) and lower length-for-age z score (P = .04) were associated independently with lower MDI at 12 months. Device-assisted feeding at 3 months (P = .04) and lower length-for-age z score (P < .05) were independently associated with lower PDI at 6 months. Both lower weight-for-age z score (P = .04) and lower length-for-age z score (P = .04) were associated independently with PDI at 12 months. CONCLUSION: Neonates with complex CHD who required device-assisted feeding and those with lower weight and length and head circumference z scores at 3 months were at risk for neurodevelopmental delay at 6 and 12 months of age.
Authors: G Wernovsky; K M Stiles; K Gauvreau; T L Gentles; A J duPlessis; D C Bellinger; A Z Walsh; J Burnett; R A Jonas; J E Mayer; J W Newburger Journal: Circulation Date: 2000-08-22 Impact factor: 29.690
Authors: Kathleen A Mussatto; Raymond G Hoffmann; George M Hoffman; James S Tweddell; Laurel Bear; Yumei Cao; Cheryl Brosig Journal: Pediatrics Date: 2014-02-02 Impact factor: 7.124
Authors: Miriam Martinez-Biarge; Victoria C Jowett; Frances M Cowan; Courtney J Wusthoff Journal: Semin Fetal Neonatal Med Date: 2013-05-23 Impact factor: 3.926
Authors: Catherine Limperopoulos; Annette Majnemer; Michael I Shevell; Charles Rohlicek; Bernard Rosenblatt; Christo Tchervenkov; H Z Darwish Journal: J Pediatr Date: 2002-07 Impact factor: 4.406
Authors: Daniel J Licht; David M Shera; Robert R Clancy; Gil Wernovsky; Lisa M Montenegro; Susan C Nicolson; Robert A Zimmerman; Thomas L Spray; J William Gaynor; Arastoo Vossough Journal: J Thorac Cardiovasc Surg Date: 2009-03 Impact factor: 5.209
Authors: Kathleen A Mussatto; Danielle Hollenbeck-Pringle; Felicia Trachtenberg; Erica Sood; Renee Sananes; Nancy A Pike; Linda M Lambert; William T Mahle; David J Goldberg; Caren S Goldberg; Carolyn Dunbar-Masterson; Michelle Otto; Bradley S Marino; Bronwyn H Bartle; Ismee A Williams; Jeffrey P Jacobs; Sinai C Zyblewski; Victoria L Pemberton Journal: Cardiol Young Date: 2017-08-29 Impact factor: 1.093
Authors: Lindsey Gakenheimer-Smith; Kristi Glotzbach; Zhining Ou; Angela P Presson; Michael Puchalski; Courtney Jones; Linda Lambert; Claudia Delgado-Corcoran; Aaron Eckhauser; Thomas Miller Journal: J Pediatr Date: 2019-08-08 Impact factor: 4.406
Authors: Nadya Golfenshtein; Alexandra L Hanlon; Janet A Deatrick; Barbara Medoff-Cooper Journal: Congenit Heart Dis Date: 2019-10-27 Impact factor: 2.007
Authors: Amy Jo Lisanti; Melanie Savoca; J William Gaynor; Maria R Mascarenhas; Chitra Ravishankar; Erin Sullivan; Karyn Pieciak; Andrew Costarino; Jodi Chen; Andrea Kennedy; Robert Olsen; Jungwon Min; Antara Mondal; Jing Huang; Sharon Y Irving Journal: J Pediatr Date: 2020-12-23 Impact factor: 4.406