T Blauwblomme1, H Lemaitre2, O Naggara3, R Calmon4, M Kossorotoff5, M Bourgeois6, B Mathon7, S Puget6, M Zerah8, F Brunelle9, C Sainte-Rose8, N Boddaert10. 1. From the Université René Descartes (T.B., O.N., R.C., B.M., S.P., M.Z., F.B., C.S.-R., N.B.), PRES Sorbonne Paris Cité, Paris, France APHP, Departments of Pediatric Neurosurgery (T.B., M.B., S.P., M.Z., C.S.-R.) French Institute of Health and Medical Research U1000 (T.B., H.L., R.C., N.B.), Institut Imagine, University Paris-Sud 11 and University Paris Descartes, Paris, France thomas.blauwblomme@nck.aphp.fr. 2. French Institute of Health and Medical Research U1000 (T.B., H.L., R.C., N.B.), Institut Imagine, University Paris-Sud 11 and University Paris Descartes, Paris, France. 3. From the Université René Descartes (T.B., O.N., R.C., B.M., S.P., M.Z., F.B., C.S.-R., N.B.), PRES Sorbonne Paris Cité, Paris, France Neuroradiology (O.N., R.C., F.B., N.B.), Hospital Necker, Paris, France Department of Neuroradiology (O.N.), French Institute of Health and Medical Research U894, Hospital Sainte-Anne, Paris, France. 4. From the Université René Descartes (T.B., O.N., R.C., B.M., S.P., M.Z., F.B., C.S.-R., N.B.), PRES Sorbonne Paris Cité, Paris, France Neuroradiology (O.N., R.C., F.B., N.B.), Hospital Necker, Paris, France French Institute of Health and Medical Research U1000 (T.B., H.L., R.C., N.B.), Institut Imagine, University Paris-Sud 11 and University Paris Descartes, Paris, France. 5. APHP, Department of Pediatric Neurology (M.K.), French Center for Pediatric Stroke, Hospital Necker, Paris, France. 6. APHP, Departments of Pediatric Neurosurgery (T.B., M.B., S.P., M.Z., C.S.-R.). 7. From the Université René Descartes (T.B., O.N., R.C., B.M., S.P., M.Z., F.B., C.S.-R., N.B.), PRES Sorbonne Paris Cité, Paris, France. 8. From the Université René Descartes (T.B., O.N., R.C., B.M., S.P., M.Z., F.B., C.S.-R., N.B.), PRES Sorbonne Paris Cité, Paris, France APHP, Departments of Pediatric Neurosurgery (T.B., M.B., S.P., M.Z., C.S.-R.). 9. From the Université René Descartes (T.B., O.N., R.C., B.M., S.P., M.Z., F.B., C.S.-R., N.B.), PRES Sorbonne Paris Cité, Paris, France Neuroradiology (O.N., R.C., F.B., N.B.), Hospital Necker, Paris, France. 10. From the Université René Descartes (T.B., O.N., R.C., B.M., S.P., M.Z., F.B., C.S.-R., N.B.), PRES Sorbonne Paris Cité, Paris, France Neuroradiology (O.N., R.C., F.B., N.B.), Hospital Necker, Paris, France French Institute of Health and Medical Research U1000 (T.B., H.L., R.C., N.B.), Institut Imagine, University Paris-Sud 11 and University Paris Descartes, Paris, France UMR 1163 (N.B.), Institut Imagine, Paris, France.
Abstract
BACKGROUND AND PURPOSE: The severity of Moyamoya disease is generally scaled with conventional angiography and nuclear medicine. Arterial spin-labeling MR imaging is now acknowledged for the noninvasive quantification of cerebral blood flow. This study aimed to analyze CBF modifications with statistical parametric mapping of arterial spin-labeling MR imaging in children undergoing an operation for Moyamoya disease. MATERIALS AND METHODS: We included 15 children treated by indirect cerebral revascularization with multiple burr-holes between 2011 and 2013. Arterial spin-labeling MR imaging and T1 sequences were then analyzed under SPM8, according to the general linear model, before and after the operation (3 and 12 months). Voxel-based analysis was performed at the group level, comparing all diseased hemispheres with all normal hemispheres and, at the individual level, comparing each patient with a control group. RESULTS: Group analysis showed statistically significant preoperative hypoperfusion in the MCA territory in the Moyamoya hemispheres and a significant increase of cerebral perfusion in the same territory after revascularization (P < .05 family-wise error-corrected). Before the operation, individual analysis showed significant hypoperfusion for each patient co-localized with the angiographic defect on DSA. All except 1 patient had improvement of CBF after revascularization, correlated with their clinical status. CONCLUSIONS: SPM analysis of arterial spin-labeling MR imaging offers a noninvasive evaluation of preoperative cerebral hemodynamic impairment and an objective assessment of postoperative improvement in children with Moyamoya disease.
BACKGROUND AND PURPOSE: The severity of Moyamoya disease is generally scaled with conventional angiography and nuclear medicine. Arterial spin-labeling MR imaging is now acknowledged for the noninvasive quantification of cerebral blood flow. This study aimed to analyze CBF modifications with statistical parametric mapping of arterial spin-labeling MR imaging in children undergoing an operation for Moyamoya disease. MATERIALS AND METHODS: We included 15 children treated by indirect cerebral revascularization with multiple burr-holes between 2011 and 2013. Arterial spin-labeling MR imaging and T1 sequences were then analyzed under SPM8, according to the general linear model, before and after the operation (3 and 12 months). Voxel-based analysis was performed at the group level, comparing all diseased hemispheres with all normal hemispheres and, at the individual level, comparing each patient with a control group. RESULTS: Group analysis showed statistically significant preoperative hypoperfusion in the MCA territory in the Moyamoya hemispheres and a significant increase of cerebral perfusion in the same territory after revascularization (P < .05 family-wise error-corrected). Before the operation, individual analysis showed significant hypoperfusion for each patient co-localized with the angiographic defect on DSA. All except 1 patient had improvement of CBF after revascularization, correlated with their clinical status. CONCLUSIONS: SPM analysis of arterial spin-labeling MR imaging offers a noninvasive evaluation of preoperative cerebral hemodynamic impairment and an objective assessment of postoperative improvement in children with Moyamoya disease.
Authors: L McKetton; L Venkatraghavan; C Rosen; D M Mandell; K Sam; O Sobczyk; J Poublanc; E Gray; A Crawley; J Duffin; J A Fisher; D J Mikulis Journal: AJNR Am J Neuroradiol Date: 2018-12-20 Impact factor: 3.825
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Authors: A N Laiwalla; F Kurth; K Leu; R Liou; J Pamplona; Y C Ooi; N Salamon; B M Ellingson; N R Gonzalez Journal: AJNR Am J Neuroradiol Date: 2017-01-19 Impact factor: 3.825
Authors: Ji Young Ha; Young Hun Choi; Seunghyun Lee; Yeon Jin Cho; Jung Eun Cheon; In One Kim; Woo Sun Kim Journal: Korean J Radiol Date: 2019-06 Impact factor: 3.500
Authors: Thomas Blauwblomme; Athena Demertzi; Jean-Marc Tacchela; Ludovic Fillon; Marie Bourgeois; Emma Losito; Monika Eisermann; Daniele Marinazzo; Federico Raimondo; Sarael Alcauter; Frederik Van De Steen; Nigel Colenbier; Steven Laureys; Volodia Dangouloff-Ros; Lionel Naccache; Nathalie Boddaert; Rima Nabbout Journal: Epilepsia Open Date: 2020-09-24