| Literature DB >> 26585163 |
Keiichiro Okuhira1, Yosuke Demizu2, Takayuki Hattori1, Nobumichi Ohoka1, Norihito Shibata1, Masaaki Kurihara2, Mikihiko Naito3.
Abstract
Manipulation of protein stability using small molecules has a great potential for both basic research and clinical therapy. Based on our protein knockdown technology, we recently developed a novel small molecule SNIPER(ER) that targets the estrogen receptor alpha (ERα) for degradation via the ubiquitin-proteasome system. This chapter describes the design and synthesis of SNIPER(ER) compounds, and methods for the evaluation of their activity in cellular system.Entities:
Keywords: Cell death; Estrogen receptor; Protein knockdown; SNIPER; Ubiquitin–proteasome system
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Year: 2016 PMID： 26585163 DOI： 10.1007/978-1-4939-3127-9_42
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745