T R Padhi1, T Das2, S Rath1, L Pradhan3, S Sutar1, K G Panda1, R Modi1, S Jalali2. 1. Miriam Hyman Children Eye Care Center, LV Prasad Eye Institute, Bhubaneswar, India. 2. Kanuri Santhamma Center for Vitreo Retinal Disease, LV Prasad Eye Institute, Banjara Hills, Hyderabad, India. 3. Infosys Pediatric Center, Capital Hospital, Bhubaneswar, India.
Abstract
PURPOSE: To evaluate the serial changes in retinal vasculature in infants treated with intravitreal bevacizumab (IVB) for aggressive posterior retinopathy of prematurity (APROP) in zone I. METHODS: Retrospective analysis of serial changes in retinal vasculature after IVB in the seven eyes of four babies with APROP in zone I. RESULTS: The initial regression, following IVB, was dramatic with reduction in vessel caliber and marked thinning and invisibility of the bridging shunts. Resurgent vascular development was very slow radially though there was continued abnormal vascular growth circumferentially. Common findings in all eyes were tangled vasculature and fine saw-toothed shunts. The variable findings were (1) new closely packed multilayered bridging shunts, long arching mature looking vessels, and finally a ridge at the periphery (n=3 eyes) at 52 weeks of postmenstrual age (PMA); (2) status quo at the stage of saw-toothed shunt and ridge in both eyes for a long time (n=2 eyes); and (3) multiple retinal hemorrhages within the vascularized retina and thick preretinal hemorrhage overlying the saw-toothed shunts and ridge that persisted for another 3 weeks and regressed 2 weeks after laser (n=1). The eyes that received bevacizumab alone (3) did not show any abnormal vascularization at 56 weeks of PMA or beyond. CONCLUSIONS: The retinal vascularization following IVB was different than normal in terms of its time, speed, and morphology; few of these changes are first to be reported in the literature (Medline search) and warrants further studies.
PURPOSE: To evaluate the serial changes in retinal vasculature in infants treated with intravitreal bevacizumab (IVB) for aggressive posterior retinopathy of prematurity (APROP) in zone I. METHODS: Retrospective analysis of serial changes in retinal vasculature after IVB in the seven eyes of four babies with APROP in zone I. RESULTS: The initial regression, following IVB, was dramatic with reduction in vessel caliber and marked thinning and invisibility of the bridging shunts. Resurgent vascular development was very slow radially though there was continued abnormal vascular growth circumferentially. Common findings in all eyes were tangled vasculature and fine saw-toothed shunts. The variable findings were (1) new closely packed multilayered bridging shunts, long arching mature looking vessels, and finally a ridge at the periphery (n=3 eyes) at 52 weeks of postmenstrual age (PMA); (2) status quo at the stage of saw-toothed shunt and ridge in both eyes for a long time (n=2 eyes); and (3) multiple retinal hemorrhages within the vascularized retina and thick preretinal hemorrhage overlying the saw-toothed shunts and ridge that persisted for another 3 weeks and regressed 2 weeks after laser (n=1). The eyes that received bevacizumab alone (3) did not show any abnormal vascularization at 56 weeks of PMA or beyond. CONCLUSIONS: The retinal vascularization following IVB was different than normal in terms of its time, speed, and morphology; few of these changes are first to be reported in the literature (Medline search) and warrants further studies.
Authors: William V Good; Robert J Hardy; Velma Dobson; Earl A Palmer; Dale L Phelps; Betty Tung; Maryann Redford Journal: Arch Ophthalmol Date: 2010-04-12
Authors: Alparslan Şahin; Muhammed Şahin; Abdullah Kürşat Cingü; Yasin Çınar; Fatih Mehmet Türkcü; Harun Yüksel; Savaş Kaya; Şeyhmus Arı; İhsan Caça Journal: Pediatr Int Date: 2013-07-30 Impact factor: 1.524
Authors: Amir H Kashani; Kevin T Brown; Emmanuel Chang; Kimberly A Drenser; Antonio Capone; Michael T Trese Journal: Ophthalmology Date: 2014-07-05 Impact factor: 12.079
Authors: Domenico Lepore; Graham E Quinn; Fernando Molle; Antonio Baldascino; Lorenzo Orazi; Maria Sammartino; Velia Purcaro; Carmen Giannantonio; Patrizia Papacci; Costantino Romagnoli Journal: Ophthalmology Date: 2014-07-04 Impact factor: 12.079
Authors: Anthony Mukwaya; Pierfrancesco Mirabelli; Anton Lennikov; Muthukumar Thangavelu; Maria Ntzouni; Lasse Jensen; Beatrice Peebo; Neil Lagali Journal: Angiogenesis Date: 2019-09-04 Impact factor: 9.596