Literature DB >> 26583565

Genes and Environment in Multiple Sclerosis project: A platform to investigate multiple sclerosis risk.

Zongqi Xia1,2,3, Charles C White1,3, Emily K Owen1, Alina Von Korff1, Sarah R Clarkson1, Cristin A McCabe3, Maria Cimpean1, Phoebe A Winn1, Ashley Hoesing1, Sonya U Steele4, Irene C M Cortese4, Tanuja Chitnis1,2, Howard L Weiner1,2, Daniel S Reich4, Lori B Chibnik1,2,3, Philip L De Jager1,2,3.   

Abstract

The Genes and Environment in Multiple Sclerosis project establishes a platform to investigate the events leading to multiple sclerosis (MS) in at-risk individuals. It has recruited 2,632 first-degree relatives from across the USA. Using an integrated genetic and environmental risk score, we identified subjects with twice the MS risk when compared to the average family member, and we report an initial incidence rate in these subjects that is 30 times greater than that of sporadic MS. We discuss the feasibility of large-scale studies of asymptomatic at-risk subjects that leverage modern tools of subject recruitment to execute collaborative projects.
© 2015 American Neurological Association.

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Year:  2015        PMID： 26583565      PMCID： PMC4778957          DOI： 10.1002/ana.24560

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  49 in total

Review 1.  Environmental risk factors for multiple sclerosis. Part II: Noninfectious factors.

Authors:  Alberto Ascherio; Kassandra L Munger
Journal:  Ann Neurol       Date:  2007-06       Impact factor: 10.422

Review 2.  Environmental factors and multiple sclerosis.

Authors:  George C Ebers
Journal:  Lancet Neurol       Date:  2008-03       Impact factor: 44.182

3.  Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score.

Authors:  Philip L De Jager; Lori B Chibnik; Jing Cui; Joachim Reischl; Stephan Lehr; K Claire Simon; Cristin Aubin; David Bauer; Jürgen F Heubach; Rupert Sandbrink; Michaela Tyblova; Petra Lelkova; Eva Havrdova; Christoph Pohl; Dana Horakova; Alberto Ascherio; David A Hafler; Elizabeth W Karlson
Journal:  Lancet Neurol       Date:  2009-10-29       Impact factor: 44.182

4.  Prevalence of radiologically isolated syndrome and white matter signal abnormalities in healthy relatives of patients with multiple sclerosis.

Authors:  T Gabelic; D P Ramasamy; B Weinstock-Guttman; J Hagemeier; C Kennedy; R Melia; D Hojnacki; M Ramanathan; R Zivadinov
Journal:  AJNR Am J Neuroradiol       Date:  2013-07-25       Impact factor: 3.825

5.  Newborn screening for HLA markers associated with IDDM: diabetes autoimmunity study in the young (DAISY).

Authors:  M Rewers; T L Bugawan; J M Norris; A Blair; B Beaty; M Hoffman; R S McDuffie; R F Hamman; G Klingensmith; G S Eisenbarth; H A Erlich
Journal:  Diabetologia       Date:  1996-07       Impact factor: 10.122

6.  Multiple sclerosis.

Authors:  Alastair Compston; Alasdair Coles
Journal:  Lancet       Date:  2008-10-25       Impact factor: 79.321

7.  Tobacco smoking, but not Swedish snuff use, increases the risk of multiple sclerosis.

Authors:  Anna K Hedström; Maria Bäärnhielm; Tomas Olsson; Lars Alfredsson
Journal:  Neurology       Date:  2009-09-01       Impact factor: 9.910

8.  Interaction between adolescent obesity and HLA risk genes in the etiology of multiple sclerosis.

Authors:  Anna Karin Hedström; Izaura Lima Bomfim; Lisa Barcellos; Milena Gianfrancesco; Catherine Schaefer; Ingrid Kockum; Tomas Olsson; Lars Alfredsson
Journal:  Neurology       Date:  2014-02-05       Impact factor: 9.910

9.  Early development of multiple sclerosis is associated with progressive grey matter atrophy in patients presenting with clinically isolated syndromes.

Authors:  Catherine M Dalton; Declan T Chard; Gerard R Davies; Katherine A Miszkiel; Dan R Altmann; Kryshani Fernando; Gordon T Plant; Alan J Thompson; David H Miller
Journal:  Brain       Date:  2004-03-03       Impact factor: 13.501

10.  Modeling disease severity in multiple sclerosis using electronic health records.

Authors:  Zongqi Xia; Elizabeth Secor; Lori B Chibnik; Riley M Bove; Suchun Cheng; Tanuja Chitnis; Andrew Cagan; Vivian S Gainer; Pei J Chen; Katherine P Liao; Stanley Y Shaw; Ashwin N Ananthakrishnan; Peter Szolovits; Howard L Weiner; Elizabeth W Karlson; Shawn N Murphy; Guergana K Savova; Tianxi Cai; Susanne E Churchill; Robert M Plenge; Isaac S Kohane; Philip L De Jager
Journal:  PLoS One       Date:  2013-11-11       Impact factor: 3.240
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  20 in total

Review 1.  Up-to-date knowledge about the association between multiple sclerosis and the reactivation of human endogenous retrovirus infections.

Authors:  Borros Arneth
Journal:  J Neurol       Date:  2018-02-08       Impact factor: 4.849

2.  Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.

Authors: 
Journal:  Science       Date:  2019-09-27       Impact factor: 47.728

Review 3.  Genomic, proteomic, and systems biology approaches in biomarker discovery for multiple sclerosis.

Authors:  Carol Chase Huizar; Itay Raphael; Thomas G Forsthuber
Journal:  Cell Immunol       Date:  2020-09-20       Impact factor: 4.868

4.  Assessment of Early Evidence of Multiple Sclerosis in a Prospective Study of Asymptomatic High-Risk Family Members.

Authors:  Zongqi Xia; Sonya U Steele; Anshika Bakshi; Sarah R Clarkson; Charles C White; Matthew K Schindler; Govind Nair; Blake E Dewey; Lauren R Price; Joan Ohayon; Lori B Chibnik; Irene C M Cortese; Philip L De Jager; Daniel S Reich
Journal:  JAMA Neurol       Date:  2017-03-01       Impact factor: 18.302

Review 5.  From the prodromal stage of multiple sclerosis to disease prevention.

Authors:  Ruth Ann Marrie; Mark Allegretta; Lisa F Barcellos; Bruce Bebo; Peter A Calabresi; Jorge Correale; Benjamin Davis; Philip L De Jager; Christiane Gasperi; Carla Greenbaum; Anne Helme; Bernhard Hemmer; Pamela Kanellis; Walter Kostich; Douglas Landsman; Christine Lebrun-Frenay; Naila Makhani; Kassandra L Munger; Darin T Okuda; Daniel Ontaneda; Ronald B Postuma; Jacqueline A Quandt; Sharon Roman; Shiv Saidha; Maria Pia Sormani; Jon Strum; Pamela Valentine; Clare Walton; Kathleen M Zackowski; Yinshan Zhao; Helen Tremlett
Journal:  Nat Rev Neurol       Date:  2022-07-15       Impact factor: 44.711

6.  The impact of socioeconomic status on subsequent neurological outcomes in multiple sclerosis.

Authors:  Devi Sai Sri Kavya Boorgu; Shruthi Venkatesh; Chirag M Lakhani; Elizabeth Walker; Ines M Aguerre; Claire Riley; Chirag J Patel; Philip L De Jager; Zongqi Xia
Journal:  Mult Scler Relat Disord       Date:  2022-06-24       Impact factor: 4.808

7.  IL-10 Gene Polymorphisms and IL-10 Serum Levels in Patients with Multiple Sclerosis in Lithuania.

Authors:  Ugne Masilionyte; Greta Gedvilaite; Kriste Kaikaryte; Alvita Vilkeviciute; Loresa Kriauciuniene; Brigita Glebauskiene; Renata Balnyte; Rasa Liutkeviciene
Journal:  Brain Sci       Date:  2022-06-18

8.  Lower Arterial Cross-Sectional Area of Carotid and Vertebral Arteries and Higher Frequency of Secondary Neck Vessels Are Associated with Multiple Sclerosis.

Authors:  P Belov; D Jakimovski; J Krawiecki; C Magnano; J Hagemeier; L Pelizzari; B Weinstock-Guttman; R Zivadinov
Journal:  AJNR Am J Neuroradiol       Date:  2017-12-07       Impact factor: 3.825

9.  Biochemically altered myelin triggers autoimmune demyelination.

Authors:  Andrew V Caprariello; James A Rogers; Megan L Morgan; Vahid Hoghooghi; Jason R Plemel; Adam Koebel; Shigeki Tsutsui; Jeffrey F Dunn; Lakshmi P Kotra; Shalina S Ousman; V Wee Yong; Peter K Stys
Journal:  Proc Natl Acad Sci U S A       Date:  2018-05-04       Impact factor: 11.205

10.  Complex relation of HLA-DRB1*1501, age at menarche, and age at multiple sclerosis onset.

Authors:  Riley Bove; Alicia S Chua; Zongqi Xia; Lori Chibnik; Philip L De Jager; Tanuja Chitnis
Journal:  Neurol Genet       Date:  2016-07-26
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