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Literature DB >> 26581517

A DNA-hairpin model for repeat-addition processivity in telomere synthesis.

Abstract

We propose a DNA-hairpin model for the processivity of telomeric-repeat addition. Concomitantly with template-RNA translocation after each repeat synthesis, the complementary DNA repeat, for example, AGGGTT, loops out in a noncanonical base-paired hairpin, thus freeing the RNA template for the next round of repeat synthesis. The DNA hairpin is temporarily stabilized by telomerase and the incoming dGTP but becomes realigned for processive telomere synthesis.

Entities: Chemical Gene Species

Mesh：

Substances：
DNA
Telomerase

Year: 2015 PMID： 26581517 PMCID： PMC6279236 DOI： 10.1038/nsmb.3098

Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369

35 in total

1. Loss and recovery of Arabidopsis-type telomere repeat sequences 5'-(TTTAGGG)(n)-3' in the evolution of a major radiation of flowering plants.

Authors: S P Adams; T P Hartman; K Y Lim; M W Chase; M D Bennett; I J Leitch; A R Leitch
Journal: Proc Biol Sci Date: 2001-08-07 Impact factor: 5.349

2. Structural basis for protein-RNA recognition in telomerase.

Authors: Jing Huang; Andrew F Brown; Jian Wu; Jing Xue; Christopher J Bley; Dustin P Rand; Lijie Wu; Rongguang Zhang; Julian J-L Chen; Ming Lei
Journal: Nat Struct Mol Biol Date: 2014-05-04 Impact factor: 15.369

3. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance.

Authors: H Huang; R Chopra; G L Verdine; S C Harrison
Journal: Science Date: 1998-11-27 Impact factor: 47.728

4. The telomerase-specific T motif is a restrictive determinant of repetitive reverse transcription by human telomerase.

Authors: William C Drosopoulos; Vinayaka R Prasad
Journal: Mol Cell Biol Date: 2009-11-16 Impact factor: 4.272

5. Structure of the Tribolium castaneum telomerase catalytic subunit TERT.

Authors: Andrew J Gillis; Anthony P Schuller; Emmanuel Skordalakes
Journal: Nature Date: 2008-08-31 Impact factor: 49.962

6. The active site residue Valine 867 in human telomerase reverse transcriptase influences nucleotide incorporation and fidelity.

Authors: William C Drosopoulos; Vinayaka R Prasad
Journal: Nucleic Acids Res Date: 2007-01-30 Impact factor: 16.971

7. How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis.

Authors: Young-Sam Lee; Yang Gao; Wei Yang
Journal: Nat Struct Mol Biol Date: 2015-03-16 Impact factor: 15.369

8. Coordinated DNA dynamics during the human telomerase catalytic cycle.

Authors: Joseph W Parks; Michael D Stone
Journal: Nat Commun Date: 2014-06-13 Impact factor: 14.919

9. Structure of active dimeric human telomerase.

Authors: Anselm Sauerwald; Sara Sandin; Gaël Cristofari; Sjors H W Scheres; Joachim Lingner; Daniela Rhodes
Journal: Nat Struct Mol Biol Date: 2013-03-10 Impact factor: 15.369

10. DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation.

Authors: Justin D Lormand; Noah Buncher; Connor T Murphy; Parminder Kaur; Marietta Y Lee; Peter Burgers; Hong Wang; Thomas A Kunkel; Patricia L Opresko
Journal: Nucleic Acids Res Date: 2013-09-13 Impact factor: 16.971

19 in total

Review 1. Telomerase Mechanism of Telomere Synthesis.

Authors: R Alex Wu; Heather E Upton; Jacob M Vogan; Kathleen Collins
Journal: Annu Rev Biochem Date: 2017-01-30 Impact factor: 23.643

Review 2. Structural biology of telomerase and its interaction at telomeres.

Authors: Yaqiang Wang; Juli Feigon
Journal: Curr Opin Struct Biol Date: 2017-07-18 Impact factor: 6.809

3. A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution.

Authors: Bishnu P Paudel; Aaron Lavel Moye; Hala Abou Assi; Roberto El-Khoury; Scott B Cohen; Jessica K Holien; Monica L Birrento; Siritron Samosorn; Kamthorn Intharapichai; Christopher G Tomlinson; Marie-Paule Teulade-Fichou; Carlos González; Jennifer L Beck; Masad J Damha; Antoine M van Oijen; Tracy M Bryan
Journal: Elife Date: 2020-07-29 Impact factor: 8.140

A DNA-hairpin model for repeat-addition processivity in telomere synthesis.

1. Loss and recovery of Arabidopsis-type telomere repeat sequences 5'-(TTTAGGG)(n)-3' in the evolution of a major radiation of flowering plants.

2. Structural basis for protein-RNA recognition in telomerase.

3. Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance.

4. The telomerase-specific T motif is a restrictive determinant of repetitive reverse transcription by human telomerase.

5. Structure of the Tribolium castaneum telomerase catalytic subunit TERT.

6. The active site residue Valine 867 in human telomerase reverse transcriptase influences nucleotide incorporation and fidelity.

7. How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis.

8. Coordinated DNA dynamics during the human telomerase catalytic cycle.

9. Structure of active dimeric human telomerase.

10. DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation.

Review 1. Telomerase Mechanism of Telomere Synthesis.

Review 2. Structural biology of telomerase and its interaction at telomeres.

3. A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution.

4. DNA-binding determinants and cellular thresholds for human telomerase repeat addition processivity.

5. How a B family DNA polymerase has been evolved to copy RNA.

Review 6. Translesion and Repair DNA Polymerases: Diverse Structure and Mechanism.

7. A single nucleotide incorporation step limits human telomerase repeat addition activity.

8. Direct observation of nucleic acid binding dynamics by the telomerase essential N-terminal domain.

Review 9. Structural biology of telomeres and telomerase.

10. Structures of telomerase at several steps of telomere repeat synthesis.