OBJECTIVE: This study aimed to examine differences in the clinical presentation of very-early-onset (VEO) and early-onset (EO) bipolar disorder (BD) not fully explored previously. METHODS: We selected two groups of subjects with BD from the Maritime Bipolar Registry based on age at onset of first major mood episode (VEO with onset prior to age 15 years; EO ranging from 15 to 18 years) and compared them with a reference group (onset after 18 years of age). There were 363 subjects (240 with bipolar I disorder and 123 with bipolar II disorder; mean age 44.2 ± 12.8 (SD) years), with 41 subjects in the VEO and 95 in the EO groups. RESULTS: In comparison with the EO and reference groups, more subjects in the VEO group developed major depression as an index episode (88% for the VEO group versus 61% for the EO group and 54% for the reference group), and had an unremitting clinical course (65% versus 42% and 42%, respectively), rapid cycling (54% versus 34% and 28%, respectively), and comorbid attention-deficit hyperactivity disorder (17% versus 1% and 3%, respectively); a higher proportion of the VEO group had first-degree relatives with affective disorders compared with the EO and reference groups (0.41 versus 0.32 and 0.29, respectively), and they had lower scores on the Global Assessment of Functioning scale (mean scores of 64 versus 70 and 70). Overall, the EO group was similar to the reference group on most measures, except for increased suicidal behavior VEO 53%, EO 44% and reference group 25%). The results of polychotomous logistic regression also support the view that VEO BD represents a rather specific subtype of BD. CONCLUSIONS: Our results suggest the recognized correlates of early-onset BD may be driven by subjects at the lowest end of the age at onset spectrum.
OBJECTIVE: This study aimed to examine differences in the clinical presentation of very-early-onset (VEO) and early-onset (EO) bipolar disorder (BD) not fully explored previously. METHODS: We selected two groups of subjects with BD from the Maritime Bipolar Registry based on age at onset of first major mood episode (VEO with onset prior to age 15 years; EO ranging from 15 to 18 years) and compared them with a reference group (onset after 18 years of age). There were 363 subjects (240 with bipolar I disorder and 123 with bipolar II disorder; mean age 44.2 ± 12.8 (SD) years), with 41 subjects in the VEO and 95 in the EO groups. RESULTS: In comparison with the EO and reference groups, more subjects in the VEO group developed major depression as an index episode (88% for the VEO group versus 61% for the EO group and 54% for the reference group), and had an unremitting clinical course (65% versus 42% and 42%, respectively), rapid cycling (54% versus 34% and 28%, respectively), and comorbid attention-deficit hyperactivity disorder (17% versus 1% and 3%, respectively); a higher proportion of the VEO group had first-degree relatives with affective disorders compared with the EO and reference groups (0.41 versus 0.32 and 0.29, respectively), and they had lower scores on the Global Assessment of Functioning scale (mean scores of 64 versus 70 and 70). Overall, the EO group was similar to the reference group on most measures, except for increased suicidal behavior VEO 53%, EO 44% and reference group 25%). The results of polychotomous logistic regression also support the view that VEO BD represents a rather specific subtype of BD. CONCLUSIONS: Our results suggest the recognized correlates of early-onset BD may be driven by subjects at the lowest end of the age at onset spectrum.
Authors: Lisa A O'Donnell; David A Axelson; Robert A Kowatch; Christopher D Schneck; Catherine A Sugar; David J Miklowitz Journal: J Affect Disord Date: 2017-04-28 Impact factor: 4.839
Authors: Lisa A O'Donnell; Alissa J Ellis; Margaret M Van de Loo; Jonathan P Stange; David A Axelson; Robert A Kowatch; Christopher D Schneck; David J Miklowitz Journal: J Affect Disord Date: 2018-04-09 Impact factor: 4.839
Authors: Danella M Hafeman; Tina R Goldstein; Michael Strober; John Merranko; Mary Kay Gill; Fangzi Liao; Rasim S Diler; Neal D Ryan; Benjamin I Goldstein; David A Axelson; Martin B Keller; Jeffrey I Hunt; Heather Hower; Lauren M Weinstock; Shirley Yen; Boris Birmaher Journal: Bipolar Disord Date: 2021-01-19 Impact factor: 5.345
Authors: Mirko Manchia; Giuseppe Maina; Bernardo Carpiniello; Federica Pinna; Luca Steardo; Virginia D'Ambrosio; Virginio Salvi; Martin Alda; Alfonso Tortorella; Umberto Albert Journal: Int J Bipolar Disord Date: 2017-08-21
Authors: Janos L Kalman; Sergi Papiol; Andreas J Forstner; Urs Heilbronner; Franziska Degenhardt; Jana Strohmaier; Mazda Adli; Kristina Adorjan; Nirmala Akula; Martin Alda; Heike Anderson-Schmidt; Till Fm Andlauer; Ion-George Anghelescu; Raffaella Ardau; Bárbara Arias; Volker Arolt; Jean-Michel Aubry; Lena Backlund; Kim Bartholdi; Michael Bauer; Bernhard T Baune; Thomas Becker; Frank Bellivier; Antonio Benabarre; Susanne Bengesser; Abesh Kumar Bhattacharjee; Joanna M Biernacka; Armin Birner; Clara Brichant-Petitjean; Monika Budde; Pablo Cervantes; Caterina Chillotti; Sven Cichon; Scott R Clark; Francesc Colom; Ashley L Comes; Cristiana Cruceanu; Piotr M Czerski; Udo Dannlowski; Alexandre Dayer; Maria Del Zompo; Jay Raymond DePaulo; Detlef E Dietrich; Bruno Étain; Thomas Ethofer; Peter Falkai; Andreas Fallgatter; Christian Figge; Laura Flatau; Here Folkerts; Louise Frisen; Mark A Frye; Janice M Fullerton; Katrin Gade; Sébastien Gard; Julie S Garnham; Fernando S Goes; Maria Grigoroiu-Serbanescu; Anna Gryaznova; Maria Hake; Joanna Hauser; Stefan Herms; Per Hoffmann; Liping Hou; Markus Jäger; Stephane Jamain; Esther Jiménez; Georg Juckel; Jean-Pierre Kahn; Layla Kassem; John Kelsoe; Sarah Kittel-Schneider; Sebastian Kliwicki; Farah Klohn-Sagatholislam; Manfred Koller; Barbara König; Carsten Konrad; Nina Lackner; Gonzalo Laje; Mikael Landén; Fabian U Lang; Catharina Lavebratt; Marion Leboyer; Susan G Leckband; Mario Maj; Mirko Manchia; Lina Martinsson; Michael J McCarthy; Susan L McElroy; Francis J McMahon; Philip B Mitchell; Marina Mitjans; Francis M Mondimore; Palmiero Monteleone; Vanessa Nieratschker; Caroline M Nievergelt; Tomas Novák; Urban Ösby; Andrea Pfennig; James B Potash; Daniela Reich-Erkelenz; Andreas Reif; Jens Reimer; Eva Reininghaus; Markus Reitt; Stephan Ripke; Guy A Rouleau; Janusz K Rybakowski; Martin Schalling; Harald Scherk; Max Schmauß; Peter R Schofield; K Oliver Schubert; Eva C Schulte; Sybille Schulz; Fanny Senner; Giovanni Severino; Tatyana Shekhtman; Paul D Shilling; Christian Simhandl; Claire M Slaney; Carsten Spitzer; Alessio Squassina; Thomas Stamm; Sophia Stegmaier; Sebastian Stierl; Pavla Stopkova; Andreas Thiel; Sarah K Tighe; Alfonso Tortorella; Gustavo Turecki; Eduard Vieta; Julia Veeh; Martin von Hagen; Moritz E Wigand; Jens Wiltfang; Stephanie Witt; Adam Wright; Peter P Zandi; Jörg Zimmermann; Markus Nöthen; Marcella Rietschel; Thomas G Schulze Journal: Bipolar Disord Date: 2018-06-28 Impact factor: 6.744
Authors: Silvia Biere; Thorsten M Kranz; Silke Matura; Kristiyana Petrova; Fabian Streit; Andreas G Chiocchetti; Oliver Grimm; Murielle Brum; Natalie Brunkhorst-Kanaan; Viola Oertel; Aliaksandr Malyshau; Andrea Pfennig; Michael Bauer; Thomas G Schulze; Sarah Kittel-Schneider; Andreas Reif Journal: Front Psychiatry Date: 2020-10-26 Impact factor: 4.157