X-Y Tao1,2, A-Z Zuo1, J-Q Wang2, F-B Tao1,2. 1. a Department of Maternal and Child Health, School of Public Health , Anhui Medical University , Hefei ; 2. b Anhui Provincial Key Laboratory of Population Health & Aristogenics , Hefei , PR China.
Abstract
OBJECTIVE: The aim of this review was to systematically evaluate the associations of all-cause, cardiovascular and all-cancer mortality with primary ovarian insufficiency (POI) and early natural menopause (ENM). METHODS: Electronic databases for relevant studies were searched up to February 28, 2015. POI and ENM were usually defined as spontaneous menopause before age 40 years and at age 40-44 years, respectively. RESULTS: A total of nine articles were derived from seven prospective cohort studies. In all studies, age of menopause was self-reported. Our meta-analysis showed that POI women had a higher risk of death from all causes (pooled relative risk (RR) 1.39, 95% confidence interval (CI) 1.10-1.77) and ischemic heart disease (IHD) (pooled RR 1.48, 95% CI 1.02-2.16) when compared with women at normal age at natural menopause (ANM). No significant association was detected from stroke and all-cancer mortality between POI women and normal ANM women. Only a slightly higher risk of death from IHD (pooled RR 1.09, 95% CI 1.00-1.18) was found when ENM women were compared with normal ANM women. CONCLUSION: The results of our study demonstrated that POI was associated with a higher risk of IHD and all-cause mortality; ENM was only associated with a slightly higher risk of IHD mortality.
OBJECTIVE: The aim of this review was to systematically evaluate the associations of all-cause, cardiovascular and all-cancer mortality with primary ovarian insufficiency (POI) and early natural menopause (ENM). METHODS: Electronic databases for relevant studies were searched up to February 28, 2015. POI and ENM were usually defined as spontaneous menopause before age 40 years and at age 40-44 years, respectively. RESULTS: A total of nine articles were derived from seven prospective cohort studies. In all studies, age of menopause was self-reported. Our meta-analysis showed that POI women had a higher risk of death from all causes (pooled relative risk (RR) 1.39, 95% confidence interval (CI) 1.10-1.77) and ischemic heart disease (IHD) (pooled RR 1.48, 95% CI 1.02-2.16) when compared with women at normal age at natural menopause (ANM). No significant association was detected from stroke and all-cancer mortality between POI women and normal ANM women. Only a slightly higher risk of death from IHD (pooled RR 1.09, 95% CI 1.00-1.18) was found when ENM women were compared with normal ANM women. CONCLUSION: The results of our study demonstrated that POI was associated with a higher risk of IHD and all-cause mortality; ENM was only associated with a slightly higher risk of IHD mortality.
Authors: Angela H E M Maas; Giuseppe Rosano; Renata Cifkova; Alaide Chieffo; Dorenda van Dijken; Haitham Hamoda; Vijay Kunadian; Ellen Laan; Irene Lambrinoudaki; Kate Maclaran; Nick Panay; John C Stevenson; Mick van Trotsenburg; Peter Collins Journal: Eur Heart J Date: 2021-03-07 Impact factor: 29.983
Authors: Veerle Dam; N Charlotte Onland-Moret; Stephen Burgess; Maria-Dolores Chirlaque; Sanne A E Peters; Ewoud Schuit; Kaja Tikk; Elisabete Weiderpass; Clare Oliver-Williams; Angela M Wood; Anne Tjønneland; Christina C Dahm; Kim Overvad; Marie-Christine Boutron-Ruault; Matthias B Schulze; Antonia Trichopoulou; Pietro Ferrari; Giovanna Masala; Vittorio Krogh; Rosario Tumino; Giuseppe Matullo; Salvatore Panico; Jolanda M A Boer; W M Monique Verschuren; Marit Waaseth; Maria José Sánchez Pérez; Pilar Amiano; Liher Imaz; Conchi Moreno-Iribas; Olle Melander; Sophia Harlid; Maria Nordendahl; Patrik Wennberg; Timothy J Key; Elio Riboli; Carmen Santiuste; Rudolf Kaaks; Verena Katzke; Claudia Langenberg; Nicholas J Wareham; Heribert Schunkert; Jeanette Erdmann; Christina Willenborg; Christian Hengstenberg; Marcus E Kleber; Graciela Delgado; Winfried März; Stavroula Kanoni; George Dedoussis; Panos Deloukas; Majid Nikpay; Ruth McPherson; Markus Scholz; Andrej Teren; Adam S Butterworth; Yvonne T van der Schouw Journal: J Clin Endocrinol Metab Date: 2022-06-16 Impact factor: 6.134