N Dressler1, A Chandra2, L Aguirre Dávila3, L M Spineli3, C Schippert1, F von Versen-Höynck4. 1. Department of Obstetrics and Gynecology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany. 2. Center for Reproductive Medicine Bad Münder, Hannoversche Straße 24, 31848, Bad Münder, Germany. 3. Institute for Biostatistics, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany. 4. Department of Obstetrics and Gynecology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany. frauke.von.versen@gmx.de.
Abstract
PURPOSE: Animal and human studies suggest that vitamin D regulates functions of the reproductive system. Vitamin D deficiency is prevalent in women of reproductive age. Vitamin D status has been associated with in vitro fertilisation outcome, features of polycystic ovarian syndrome (PCOS) and endometriosis. The aims of our study were to investigate the prevalence of vitamin D deficiency of infertile women living in central Germany, to identify risk factors for vitamin D deficiency and to specify seasonal variations of vitamin D status. METHODS: This was a retrospective cohort study at an academic tertiary care centre (N = 113) and an Outpatient Centre for Reproductive Medicine (N = 193) of women presenting for infertility treatment. The statistical evaluation was descriptive and explorative. Possible risk factors associated with an increased risk for vitamin D deficiency were assessed using multiple logistic regression models. Variables with p value less than 0.05 were further assessed in a multivariable logistic regression model. RESULTS: Overall, 98.2 % of patients at centre 1 and 81.3 % of women with impaired fertility at centre 2 had deficient or insufficient vitamin D levels. Overweight BMI and limited exposure to sun (winter, spring and autumn trimester) were associated with an increased risk of vitamin D deficiency. Vitamin D levels did not vary according to age or infertility associated disorders (e.g. endometriosis, PCOS). CONCLUSION: The rate of vitamin D deficiency among women with impaired fertility is alarming. Prospective studies are pressingly needed to confirm a causal relationship and to investigate the potential therapeutic benefits of vitamin D supplementation in this population.
PURPOSE: Animal and human studies suggest that vitamin D regulates functions of the reproductive system. Vitamin D deficiency is prevalent in women of reproductive age. Vitamin D status has been associated with in vitro fertilisation outcome, features of polycystic ovarian syndrome (PCOS) and endometriosis. The aims of our study were to investigate the prevalence of vitamin Ddeficiency of infertilewomen living in central Germany, to identify risk factors for vitamin D deficiency and to specify seasonal variations of vitamin D status. METHODS: This was a retrospective cohort study at an academic tertiary care centre (N = 113) and an Outpatient Centre for Reproductive Medicine (N = 193) of women presenting for infertility treatment. The statistical evaluation was descriptive and explorative. Possible risk factors associated with an increased risk for vitamin D deficiency were assessed using multiple logistic regression models. Variables with p value less than 0.05 were further assessed in a multivariable logistic regression model. RESULTS: Overall, 98.2 % of patients at centre 1 and 81.3 % of women with impaired fertility at centre 2 had deficient or insufficientvitamin D levels. Overweight BMI and limited exposure to sun (winter, spring and autumn trimester) were associated with an increased risk of vitamin D deficiency. Vitamin D levels did not vary according to age or infertility associated disorders (e.g. endometriosis, PCOS). CONCLUSION: The rate of vitamin D deficiency among women with impaired fertility is alarming. Prospective studies are pressingly needed to confirm a causal relationship and to investigate the potential therapeutic benefits of vitamin D supplementation in this population.
Entities:
Keywords:
BMI; Female; Infertility; Season; Vitamin D
Authors: Vitor As Deriquehem; Roberto A Antunes; Mila W Reginatto; Ana C Mancebo; Patricia Areas; Enrrico Bloise; Maria do Carmo B de Souza; Tania M Ortiga-Carvalho Journal: JBRA Assist Reprod Date: 2016-08-01