Lisa M Bodnar1,2,3, Lara L Siminerio1, Katherine P Himes2,3, Jennifer A Hutcheon4, Timothy L Lash5, Sara M Parisi1, Barbara Abrams6. 1. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 2. Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 3. Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA. 4. Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada. 5. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA. 6. Division of Epidemiology, University of California at Berkeley School of Public Health, Berkeley, California, USA.
Abstract
OBJECTIVE: Assessment of the joint and independent relationships of gestational weight gain and prepregnancy body mass index (BMI) on risk of infant mortality was performed. METHODS: This study used Pennsylvania linked birth-infant death records (2003-2011) from infants without anomalies born to mothers with prepregnancy BMI categorized as underweight (n = 58,973), normal weight (n = 610,118), overweight (n = 296,630), grade 1 obesity (n = 147,608), grade 2 obesity (n = 71,740), and grade 3 obesity (n = 47,277). Multivariable logistic regression models stratified by BMI category were used to estimate dose-response associations between z scores of gestational weight gain and infant death after confounder adjustment. RESULTS: Infant mortality risk was lowest among normal-weight women and increased with rising BMI category. For all BMI groups except for grade 3 obesity, there were U-shaped associations between gestational weight gain and risk of infant death. Weight loss and very low weight gain among women with grades 1 and 2 obesity were associated with high risks of infant mortality. However, even when gestational weight gain in women with obesity was optimized, the predicted risk of infant death remained higher than that of normal-weight women. CONCLUSIONS: Interventions aimed at substantially reducing preconception weight among women with obesity and avoiding very low or very high gestational weight gain may reduce risk of infant death.
OBJECTIVE: Assessment of the joint and independent relationships of gestational weight gain and prepregnancy body mass index (BMI) on risk of infant mortality was performed. METHODS: This study used Pennsylvania linked birth-infant death records (2003-2011) from infants without anomalies born to mothers with prepregnancy BMI categorized as underweight (n = 58,973), normal weight (n = 610,118), overweight (n = 296,630), grade 1 obesity (n = 147,608), grade 2 obesity (n = 71,740), and grade 3 obesity (n = 47,277). Multivariable logistic regression models stratified by BMI category were used to estimate dose-response associations between z scores of gestational weight gain and infantdeath after confounder adjustment. RESULTS:Infant mortality risk was lowest among normal-weight women and increased with rising BMI category. For all BMI groups except for grade 3 obesity, there were U-shaped associations between gestational weight gain and risk of infantdeath. Weight loss and very low weight gain among women with grades 1 and 2 obesity were associated with high risks of infant mortality. However, even when gestational weight gain in women with obesity was optimized, the predicted risk of infantdeath remained higher than that of normal-weight women. CONCLUSIONS: Interventions aimed at substantially reducing preconception weight among women with obesity and avoiding very low or very high gestational weight gain may reduce risk of infantdeath.
Authors: Laura Schummers; Jennifer A Hutcheon; Lisa M Bodnar; Ellice Lieberman; Katherine P Himes Journal: Obstet Gynecol Date: 2015-01 Impact factor: 7.661
Authors: Jennifer A Hutcheon; Robert W Platt; Barbara Abrams; Katherine P Himes; Hyagriv N Simhan; Lisa M Bodnar Journal: Obesity (Silver Spring) Date: 2015-03 Impact factor: 5.002
Authors: Lisa M Bodnar; Jennifer A Hutcheon; Sara M Parisi; Sarah J Pugh; Barbara Abrams Journal: Paediatr Perinat Epidemiol Date: 2014-12-10 Impact factor: 3.980
Authors: Lara S Lemon; Ashley I Naimi; Barbara Abrams; Jay S Kaufman; Lisa M Bodnar Journal: Obesity (Silver Spring) Date: 2016-12 Impact factor: 5.002
Authors: Lisa M Bodnar; Katherine P Himes; Barbara Abrams; Timothy L Lash; Sara M Parisi; Cara L Eckhardt; Betty J Braxter; Sarah Minion; Jennifer A Hutcheon Journal: Obstet Gynecol Date: 2019-11 Impact factor: 7.661
Authors: Edwin A Mitchell; Xiaohan Yan; Shirley You Ren; Tatiana M Anderson; Jan-Marino Ramirez; Juan M Lavista Ferres; Richard Johnston Journal: J Pediatr Date: 2020-02-12 Impact factor: 4.406
Authors: Stephanie A Leonard; Barbara Abrams; Elliott K Main; Deirdre J Lyell; Suzan L Carmichael Journal: Am J Clin Nutr Date: 2020-04-01 Impact factor: 7.045
Authors: Jasper Most; Abby D Altazan; Daniel S Hsia; Robbie A Beyl; Leanne M Redman Journal: Obesity (Silver Spring) Date: 2019-12-31 Impact factor: 5.002