| Literature DB >> 26571076 |
Charles E Mowbray1, Stéphanie Braillard1, William Speed1, Paul A Glossop2, Gavin A Whitlock2, Karl R Gibson2, James E J Mills2, Alan D Brown3, J Mark F Gardner4, Yafeng Cao5, Wen Hua5, Garreth L Morgans6, Pim-Bart Feijens7, An Matheeussen7, Louis J Maes7.
Abstract
Visceral leishmaniasis is a severe parasitic disease that is one of the most neglected tropical diseases. Treatment options are limited, and there is an urgent need for new therapeutic agents. Following an HTS campaign and hit optimization, a novel series of amino-pyrazole ureas has been identified with potent in vitro antileishmanial activity. Furthermore, compound 26 shows high levels of in vivo efficacy (>90%) against Leishmania infantum, thus demonstrating proof of concept for this series.Entities:
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Year: 2015 PMID： 26571076 DOI： 10.1021/acs.jmedchem.5b01456
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446