BACKGROUND: Fermentable carbohydrates (FCHO) have been shown to improve insulin sensitivity in normoglycaemic and insulin-resistant subjects. However, there are no data on subjects with prediabetes. We aimed to investigate the effect of the FCHO inulin, on glucose homeostasis in subjects with prediabetes. METHODS: In a double-blind and placebo-controlled crossover study, 40 volunteers with prediabetes were randomly allocated to take 30 g/day of inulin or cellulose for 2 weeks in a crossover trial, following a 4-week dose-escalation run-in. Fasting insulin and glucose were measured for all subjects. Fifteen of the 40 subjects also underwent a meal tolerance test to assess insulin sensitivity, free fatty acids and glucagon-like peptide-1 concentrations. A subanalysis was carried out to examine any differences between the prediabetes subtypes. RESULTS: Inulin was associated with a significant increase in (0-30 min)incremental AUC (iAUC) for insulin (treatment: p < 0.04) and (0-60 min)iAUC for insulin (treatment: p < 0.04) compared to control. There was a significant reduction in insulin resistance measured by the homeostatic model assessment in the isolated-impaired fasting glucose (p < 0.05) but not in the isolated-impaired glucose tolerance groups (p = 0.59). CONCLUSION: The FCHO, inulin, may have unique metabolic effects that are of particular benefit to people at risk of diabetes, which warrant further investigation.
BACKGROUND: Fermentable carbohydrates (FCHO) have been shown to improve insulin sensitivity in normoglycaemic and insulin-resistant subjects. However, there are no data on subjects with prediabetes. We aimed to investigate the effect of the FCHO inulin, on glucose homeostasis in subjects with prediabetes. METHODS: In a double-blind and placebo-controlled crossover study, 40 volunteers with prediabetes were randomly allocated to take 30 g/day of inulin or cellulose for 2 weeks in a crossover trial, following a 4-week dose-escalation run-in. Fasting insulin and glucose were measured for all subjects. Fifteen of the 40 subjects also underwent a meal tolerance test to assess insulin sensitivity, free fatty acids and glucagon-like peptide-1 concentrations. A subanalysis was carried out to examine any differences between the prediabetes subtypes. RESULTS: Inulin was associated with a significant increase in (0-30 min)incremental AUC (iAUC) for insulin (treatment: p < 0.04) and (0-60 min)iAUC for insulin (treatment: p < 0.04) compared to control. There was a significant reduction in insulin resistance measured by the homeostatic model assessment in the isolated-impaired fasting glucose (p < 0.05) but not in the isolated-impaired glucose tolerance groups (p = 0.59). CONCLUSION: The FCHO, inulin, may have unique metabolic effects that are of particular benefit to people at risk of diabetes, which warrant further investigation.
Authors: Edward S Chambers; Claire S Byrne; Douglas J Morrison; Kevin G Murphy; Tom Preston; Catriona Tedford; Isabel Garcia-Perez; Sofia Fountana; Jose Ivan Serrano-Contreras; Elaine Holmes; Catherine J Reynolds; Jordie F Roberts; Rosemary J Boyton; Daniel M Altmann; Julie A K McDonald; Julian R Marchesi; Arne N Akbar; Natalie E Riddell; Gareth A Wallis; Gary S Frost Journal: Gut Date: 2019-04-10 Impact factor: 23.059
Authors: Annabel Biruete; Tzu-Wen L Cross; Jacob M Allen; Brandon M Kistler; Henriette de Loor; Pieter Evenepoel; George C Fahey; Laura Bauer; Kelly S Swanson; Kenneth R Wilund Journal: J Ren Nutr Date: 2021-06-11 Impact factor: 4.354
Authors: Anouk Gijbels; Inez Trouwborst; Kelly M Jardon; Gabby B Hul; Els Siebelink; Suzanne M Bowser; Dilemin Yildiz; Lisa Wanders; Balázs Erdos; Dick H J Thijssen; Edith J M Feskens; Gijs H Goossens; Lydia A Afman; Ellen E Blaak Journal: Front Nutr Date: 2021-06-30