| Literature DB >> 26567956 |
Barbara Alberter1, Christoph A Klein1,2, Bernhard Polzer1.
Abstract
The generation of variant cancer cells is the major cause of acquired resistance against systemic therapies and consequently, of our inability to cure advanced cancer patients. Circulating tumor cells are gaining increasing clinical attention because they may enable the monitoring cancer progression and adjustment of treatment. In recent years multiple technologies for enrichment, isolation as well as molecular and functional analysis of circulating tumor cells have been developed. Implementation of these technologies in standardized and automated workflows in clinical diagnostics could provide valuable information for real-time monitoring of cancer and eventually new therapeutic strategies for the benefit of patients.Entities:
Keywords: CTC cultivation; circulating tumor cells; liquid biopsy; molecular single-cell analysis; whole genome amplification
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Year: 2015 PMID： 26567956 DOI： 10.1586/14737159.2016.1121099
Source DB: PubMed Journal: Expert Rev Mol Diagn ISSN： 1473-7159 Impact factor: 5.225